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  • 1
    Electronic Resource
    Electronic Resource
    Diffusion of intramuscular ketoprofen into the cerebrospinal fluid (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 319-321 
    Details
    ISSN: 1432-1041
    Keywords: ketoprofen ; diffusion ; cerebrospinal Fluid ; CSF level ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Serum and cerebrospinal fluid (CSF) concentrations of ketoprofen have been measured in 36 patients hospitalised for sciatica. Diagnostic lumbar puncture was done 15 min to 13 h after a single 100 mg intramuscular dose of ketoprofen. Serum and CSF were sampled at the same time. Free serum concentrations were determined by equilibrium dialysis. Total and free concentrations were assayed by a highly sensitive and specific HPLC method. Ketoprofen rapidly crossed the blood-brain barrier and was detected in CSF 15 min after its administration. The rapid diffusion can be explained by the high lipid solubility of the drug. The CSF level was in equilibrium with the free serum concentration from the second to the 13th hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544088
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma and cerebrospinal fluid concentrations of indomethacin in humans (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 343-346 
    Details
    ISSN: 1432-1041
    Keywords: indomethacin ; cerebrospinal fluid ; pharmacokinetics ; protein binding ; analgesic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma and cerebrospinal fluid (CSF) concentrations of indomethacin have been determined in 52 patients hospitalized for nerve-root compression pain. Samples of blood and CSF were collected at the same time in each subject, 0.5 to 12 h after a single intramuscular injection of 50 mg indomethacin. Analgesic effect was assessed by the absolute and percentage variation in Huskisson's visual analogue scale between dosing and sampling. According to its high lipid solubility, indomethacin rapidly crossed the blood-brain barrier, being detected in CSF 0.5 h after administration. After attainment of equilibrium within 2 h, the CSF level exceeded the free plasma level. Since the drug was extensively bound to serum albumin (99.7±0.1%), this phenomenon may represent a slight degree of binding of indomethacin in CSF. The analgesic activity was not related to either the plasma or CSF concentration of indomethacin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315572
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  • 3
    Electronic Resource
    Electronic Resource
    Thermal effects of a laser beam on the electrodeposition of Ni–P alloys (1997)
    Springer
    Journal of applied electrochemistry 28 (1997), S. 80-88 
    Details
    ISSN: 1572-8838
    Keywords: Ni– P alloys ; electrodeposition ; acetate electrolyte ; hypophosphite ; continuous and pulsed laser ; thermal effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The paper deals with the effects of an incident laser beam on electrodeposition of Ni–P alloys from dilute acetate solutions. The kinetics of separate reductions of Ni2+ and H2PO−2 species were first investigated by linear sweep voltammetry, varying the hypophosphite concentration and the solution temperature: comparison of the kinetically limited current densities of the two reductions suggested that increasing temperature might reduce the significance of P codeposition. This tendency was confirmed by deposition runs carried out at controlled current. Deposition performance was discussed in terms of faradaic yield and deposit properties, namely P content together with the aspect and the structure of the alloys. Use of a continuous or pulsed laser beam was shown to reduce the P content in the deposit at high current densities; in some cases, amorphous structures were replaced by more crystalline forms with assistance of a laser beam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003253903124
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