Summary
Serum and cerebrospinal fluid (CSF) concentrations of ketoprofen have been measured in 36 patients hospitalised for sciatica. Diagnostic lumbar puncture was done 15 min to 13 h after a single 100 mg intramuscular dose of ketoprofen. Serum and CSF were sampled at the same time. Free serum concentrations were determined by equilibrium dialysis. Total and free concentrations were assayed by a highly sensitive and specific HPLC method. Ketoprofen rapidly crossed the blood-brain barrier and was detected in CSF 15 min after its administration. The rapid diffusion can be explained by the high lipid solubility of the drug. The CSF level was in equilibrium with the free serum concentration from the second to the 13th hours.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bonati M, Kanto J, Tognoni G (1982) Clinical pharmacokinetics of cerebrospinal fluid. Clin Pharmacol 7: 312–335
Ferreira SH, Lorenzetti BB, Correa FMA (1978) Central and peripheral antianalgesic action of aspirin-like drugs. Eur J Pharmacol 53: 39–48
Fink M, Irwin P (1982) Central nervous system effect of aspirin. Clin Pharmacol Ther 32: 362–365
Gaucher A, Netter P, Faure G, Schoeller JP, Gerardin A (1983) Diffusion of oxyphenbutazone into synovial fluid, synovial tissue, joint cartilage and cerebrospinal fluid. Eur J Clin Pharmacol 25: 105–112
Mason J, Bolton MS (1977) A general practice assessment of Alrheumat (ketoprofen) in the treatment of rheumatic conditions. J Clin Pract 31: 127–134
Mayer S, Maickel RP, Brodie BB (1959) Kinetics of penetration of drugs and other foreign compounds into cerebrospinal fluid and brain. J Pharmacol Exp Ther 127: 205–211
Tamisier JN (1978) Ketoprofen Clin Rheum Dis 5: 381–391
Upton RA, Buskin JN, Guentert TW, Williams RL, Riegelman S (1980) Convenient and sensitive high performance liquid chromatography assay for ketoprofen, naproxen and other allied drugs in plasma or urine. J Chromatogr 190: 119–128
Vrhovac B (1984) Antiinflammatory analgesics and drugs used in gout. In Dukes MNG (ed) Meyler's side effects of drugs. Elsevier, Amsterdam 151–182
Werbeeck RK, Blackburn JL, Loewen GR (1983) Clinical pharmacokinetic of non-steroidal antiinflammatory drugs. Clin Pharmacokinet 8: 297–331
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Netter, P., Lapicque, F., Bannwarth, B. et al. Diffusion of intramuscular ketoprofen into the cerebrospinal fluid. Eur J Clin Pharmacol 29, 319–321 (1985). https://doi.org/10.1007/BF00544088
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00544088