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  • 1
    Electronic Resource
    Electronic Resource
    Structured biological modelling: a method for the analysis and simulation of biological systems applied to oscillatory intracellular calcium waves
    Amsterdam : Elsevier
    Biosystems 27 (1992), S. 145-169 
    Details
    ISSN: 0303-2647
    Keywords: Oscillatory calcium waves ; Signal transduction ; Stochastic simulation ; Structured Biological Modelling ; Systems analysis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0303-2647(92)90070-F
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  • 2
    Electronic Resource
    Electronic Resource
    Systems analysis in cell biology: From the phenomenological description towards a computer model of the intracellular signal transduction network (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 245-257 
    Details
    ISSN: 1420-9071
    Keywords: Structured analysis ; mathematical modelling ; stochastic simulation ; cell cycle control ; tumor biology ; calcium oscillations ; signal transduction ; Structured Biological Modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In this paper we introduce a systematic approach for the modelling of complex biological systems which is especially useful for the analysis of signal transduction mechanisms in cell biology. It is shown that systems analysis in form of top-down levelled dataflow diagrams provides a powerful tool for the mathematical modelling of the system in terms of a stochastic formulation. Due to the exact formulation, the consistency of the model with the experimental results can be tested by means of a computer simulation. The method termed Structured Biological Modelling (SBM) is illustrated by modelling some aspects of the second messenger network which regulates cell proliferation. As an example for the strainghtforward development of a mathematical description a stochastic computer model for intracellular Ca2+ oscillations is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923534
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  • 3
    Electronic Resource
    Electronic Resource
    Presence of a transposon-like element in the promoter region of an inactive patatin gene in Solanum tuberosum L. (1990)
    Springer
    Plant molecular biology 14 (1990), S. 239-247 
    Details
    ISSN: 1573-5028
    Keywords: patatin ; potato ; transposon ; gene inactivation ; β-glucuronidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The promoter of the PGT3 patatin gene belonging to the class II subfamily is highly homologous to other class II patatin genes except for a 736 bp insertion in front of the putative transcription start site. The insertion is characterized by structural features resembling a transposable element such as an 11 bp inverted repeat at the termini and an 8 bp duplication flanking the insertion site. Despite the high homology to active patatin genes, fusion of its promoter to the β-glucuronidase reporter gene does not lead to detectable β-glucuronidase (GUS) activity in transgenic potato or tobacco plants, suggesting that the inactivation of this gene might be caused by the insertion of the transposon like element.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00018564
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  • 4
    Electronic Resource
    Electronic Resource
    A detailed study of the regulation and evolution of the two classes of patatin genes in Solanum tuberosum L. (1991)
    Springer
    Plant molecular biology 17 (1991), S. 1139-1154 
    Details
    ISSN: 1573-5028
    Keywords: patatin ; promoter ; β-glucuronidase ; potato
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The class-specific expression of patatin genes was investigated by analysing four new patatin genes. A class I patatin gene from cv. Berolina as well as a class I and two class II patatin genes from the monohaploid cultivar AM 80/5793 were isolated and partially sequenced. Sequence comparison indicates rearrangements as the major source for the generation of diversity between the different members of the classes. The expression of single genes was studied in potato plants transformed with chimaeric genes where the putative patatin promoters were fused to the GUS reporter gene. A detailed histochemical analysis reveals that both class I genes are expressed as the previously described class I patatin gene B33 from cv. Berolina [1], i.e. in the starch-containing cells of potato tubers and in sucrose-induced leaves. The class II gene pgT12 shows the same pattern as the previously described class II gene pgT2 [2], i.e. expression in root tips and in the vascular tissue of tubers, whereas no activity was detectable for pgT4. Thus the expression pattern of both classes of genes seems to be stable at least within or even between different cultivars.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00028731
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