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  • Electronic structure and strongly correlated systems  (4)
  • multidrug resistance  (2)
  • 1
    Publication Date: 2011-01-11
    Description: Author(s): P. Kusar, T. Mertelj, V. V. Kabanov, J.-H. Chu, I. R. Fisher, H. Berger, L. Forró, and D. Mihailovic The anharmonic response of charge-density wave (CDW) order to strong laser-pulse perturbations in 1 T-TaS_{2} and TbTe_{3} is investigated by means of multiple-pump-pulse time-resolved femtosecond optical spectroscopy. We observe remarkable anharmonic effects hitherto undetected in systems exhibit... [Phys. Rev. B 83, 035104] Published Mon Jan 10, 2011
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2017-02-04
    Description: Author(s): M. Beck, M. Klammer, I. Rousseau, M. Obergfell, P. Leiderer, M. Helm, V. V. Kabanov, I. Diamant, A. Rabinowicz, Y. Dagan, and J. Demsar In the conventional theory of superconductivity the critical temperature Tc is determined by the electron-phonon coupling constant and the phonon cut-off frequency. The hallmark experiments of McMillan and Rowell demonstrated that bosons (phonons) responsible for pairing can be observed through the frequency dependence of the gap parameter. Determination of the electron-boson coupling strength in high- T c cuprates is, however, not an easy task. One of the promising ways is to measure the energy relaxation rate of photoexcited carriers by using femtosecond real-time techniques. Here, considering the electron relaxation process within the conduction band, it is commonly assumed that the underlying Eliashberg electron-boson coupling function is independent of electron excess energy. Conversely, studies of light-induced suppression of superconductivity in Pr 1 . 85 Ce 0 . 15 CuO 4 reported here imply a strong variation of the electron-boson coupling function on electron energy. Considering the competing scenarios of superconductivity being mediated by either phonons or magnetic excitations, the results suggest that high-energy electrons strongly couple either to phonons or magnetic modes, while the situation is reversed when considering pairing of low-energy electrons. [Phys. Rev. B 95, 085106] Published Fri Feb 03, 2017
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 3
    Publication Date: 2014-01-07
    Description: Author(s): H. Schaefer, V. V. Kabanov, and J. Demsar The interplay between the electronic and structural subsystems has strong implications on the character of collective excitations in cooperative systems. Their detailed understanding can provide important information on the coupling mechanisms and coupling strengths in such systems. With the recent ... [Phys. Rev. B 89, 045106] Published Mon Jan 06, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 4
    Publication Date: 2014-03-05
    Description: Author(s): V. V. Baranov and V. V. Kabanov The theory of the electron relaxation in simple metals excited by an ultrashort optical pump is developed on the basis of the solution of the linearized Boltzmann kinetic equation. The kinetic equation includes both the electron-electron and the electron-phonon collision integrals and assumes that F... [Phys. Rev. B 89, 125102] Published Tue Mar 04, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 5
    ISSN: 1573-904X
    Keywords: block copolymer ; cancer ; multidrug resistance ; Pluronic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. Using monolayers of human pancreatic adenocarcinoma cells (Panc-1) that express multidrug resistance-associated protein (MRP), the present work investigates the effects of Pluronic block copolymers on the functional activity of MRP. Methods. The studies examined the accumulation and efflux of the MRP selective probe fluorescein (FLU) in Panc-1 cell monolayers with and without Pluronic P85 (P85), Pluronic L81 (L81) and Pluronic F108 (F108). Results. Treatment of Panc-1 cells with P85 resulted in concentration-dependent increases in FLU accumulation and elimination of FLU sequestration in vesicular compartments in these cells. The effects of P85 were selective for FLU in the Panc-1 cell monolayers. Inhibition of MRP-mediated transport was dependent on the composition of Pluronic block copolymer: the more hydrophobic copolymer had the greater effect on FLU uptake in Panc-1 monolayers (L81 〉 P85 〉 F108). Conclusions. This paper demonstrates for the first time that Pluronic block copolymers inhibit multidrug resistance-associated protein (MRP). The similarities in the effects of Pluronic block copolymers on MRP and P-glycoprotein drug efflux systems suggest that a single unifying mechanism may explain the inhibition observed.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-904X
    Keywords: doxorubicin ; rhodamine ; multidrug resistance ; Pluronic ; block copolymers ; hypersensitization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. Previous studies have demonstrated that Pluronic block copolymers hypersensitize multiple drug resistant (MDR) cancer cells, drastically increasing the cytotoxic effects of anthracyclines and other anticancer cytotoxics in these cells. This work evaluates the dose dependent effects of these polymers on (i) doxorubicin (Dox) cytotoxicity and (ii) cellular accumulation of P-glycoprotein probe, rhodamine 123 (R123) in MDR cancer cells. Methods. Dox cytotoxicity and R123 accumulation studies are performed on monolayers of drug-sensitive (KB, MCF-7, Aux-Bl) and MDR (KBv, MCF-7/ADR, CHrC5) cells. Results. Both tests reveal strong effects of Pluronic copolymers observed at concentrations below the critical micelle concentration (CMC) and suggest that these effects are due to the copolymer single chains ('unimers'). Using block copolymers with various lengths of hydrophobic propylene oxide (PO) and hydrophilic ethylene oxide (EO) segments these studies suggest that the potency of Pluronic unimers in MDR cells increases with elevation of the hydrophobicity of their molecule. Optimization of Pluronic composition in R123 accumulation and Dox cytotoxicity studies reveals that Pluronic copolymers with intermediate lengths of PO chains and relatively short EO segments have the highest net efficacy in MDR cells. Conclusions. The relationship between the structure of Pluronic block copolymers and their biological response modifying effects in MDR cells is useful for determining formulations with maximal efficacy with respect to MDR tumors.
    Type of Medium: Electronic Resource
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