ISSN:
1573-3297
Keywords:
mice
;
selective breeding
;
selection
;
analgesia
;
antinociception
;
levorphanol
;
morphine
;
hot plate test
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Psychology
Notes:
Abstract Beginning with a genetically heterogeneous outbred stock of mice (Binghamton HET), selective breeding was conducted within two selected lines for a high analgesic (antinociceptive) response and a low analgesic response, respectively, to a narcotic analgesic (levorphanol tartrate) using the hot-plate test. A nonselected control line was also maintained concurrently. Four generations of predominantly mass selection have produced a marked divergence between the two oppositely selected lines, yielding a realized heritability (h 2) of 0.32±0.05. The selection response was markedly asymmetrical, with a realizedh 2 in the high direction of 0.45±0.10 and in the low direction of 0.12±0.07. These animals represent potentially useful subject material for research concerning the mechanisms and correlates of opiate-induced analgesia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01065776
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