Abstract
Beginning with a genetically heterogeneous outbred stock of mice (Binghamton HET), selective breeding was conducted within two selected lines for a high analgesic (antinociceptive) response and a low analgesic response, respectively, to a narcotic analgesic (levorphanol tartrate) using the hot-plate test. A nonselected control line was also maintained concurrently. Four generations of predominantly mass selection have produced a marked divergence between the two oppositely selected lines, yielding a realized heritability (h 2) of 0.32±0.05. The selection response was markedly asymmetrical, with a realizedh 2 in the high direction of 0.45±0.10 and in the low direction of 0.12±0.07. These animals represent potentially useful subject material for research concerning the mechanisms and correlates of opiate-induced analgesia.
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This work was supported by NIDA Grant DA 02723 awarded to JKB.
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Belknap, J.K., Haltli, N.R., Goebel, D.M. et al. Selective breeding for high and low levels of opiate-induced analgesia in mice. Behav Genet 13, 383–396 (1983). https://doi.org/10.1007/BF01065776
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DOI: https://doi.org/10.1007/BF01065776