ISSN:
1420-9071
Keywords:
Glutamate
;
high affinity uptake
;
hippocampus
;
insect toxins
;
β-PTX
;
δ-PTX
;
polyamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Two components of the venom of the predatory waspPhilanthus triangulum F. significantly reduce — to a greater or less extent — the high affinity uptake of glutamate in rat hippocampus. A concentration of 10 μM δ-PTX caused a reduction of 74%, while the other component, β-PTX, at the same concentration, caused a reduction of 18%. Hence the effect of δ-PTX on high affinity glutamate uptake in the hippocampus is comparable with its effect on high affinity glutamate uptake in insect neuromuscular junctions. Contrary to our previous findings that β-PTX has no effect on high affinity glutamate uptake in insect glutamatergic terminal axons, however, β-PTX significantly reduces high affinity glutamate uptake in the hippocampus, albeit less effectively than δ-PTX.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01952444
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