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Presynaptic effects of spider toxins: Increase of high affinity uptake in the arthropod peripheral glutamatergic system

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Summary

In contrast to the reported effects of polyamines on the high affinity neurotransmitter uptake, two polyamine-like spider toxins significantly increase the high affinity uptake of glutamate as demonstrated with high resolution autoradiography. The effects of both spider toxins were compared to those of a polyamine toxin from the waspPhilanthus triangulum, which is known to inhibit the high affinity glutamate uptake.

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Authors and Affiliations

  1. Department of Electron Microscopy, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, NL-1105 AZ, Amsterdam, The Netherlands

    J. van Marle, T. Piek, H. Karst, A. Lind & J. van Weeren-Kramer

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  1. J. van Marle
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  2. T. Piek
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  3. H. Karst
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  4. A. Lind
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  5. J. van Weeren-Kramer
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van Marle, J., Piek, T., Karst, H. et al. Presynaptic effects of spider toxins: Increase of high affinity uptake in the arthropod peripheral glutamatergic system. Experientia 45, 155–156 (1989). https://doi.org/10.1007/BF01954856

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  • DOI: https://doi.org/10.1007/BF01954856

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