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  • gastric adenocarcinoma  (2)
  • teniposide  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    VM-26 in gastric cancer (1993)
    Springer
    Investigational new drugs 11 (1993), S. 333-334 
    Details
    ISSN: 1573-0646
    Keywords: teniposide ; gastric cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The Southwest Oncology Group conducted a trial of VM-26 (teniposide) in patients with advanced gastric cancer. VM-26 60 mg/m2 IV infusion over 30–45 minutes was given daily for 5 days every 21 days. Twentyone eligible patients with measurable disease and a SWOG performance status of 0–2 were analyzed for response and toxicity. Partial responses were seen in 2 of the 21 eligible patients (9.5%). Median survival was 3.8 months. Severe or life-threatening toxicity was observed in 13/21 (62%) patients. This included two drug related deaths related to neutropenic sepsis and seven other patients with grade 4 granulocytopenia (〈 500/mm3). Liver dysfunction and hypotension were seen less often and were not dose limiting. Although the modest activity seen was comparable to that of VP-16 (etoposide) as a single agent, the hematologic toxicity observed in this trial would likely preclude further trials of VM-26 (teniposide) in advanced gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00874433
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  • 2
    Electronic Resource
    Electronic Resource
    Phase II trial of piroxantrone in gastric carcinoma (1994)
    Springer
    Investigational new drugs 12 (1994), S. 159-161 
    Details
    ISSN: 1573-0646
    Keywords: piroxantrone ; gastric adenocarcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-one evaluable patients with advanced gastric adenocarcinoma were treated with piroxantrone at a dose of 150 mg/m2 intravenously every 21 days. One objective response was seen for an overall response rate of 5% (95% confidence interval 0–24%). Toxicities of grade ≥ 3 were primarily hematologie and seen in 13/21 patients. Piroxantrone has minimal activity against gastric adenocarcinoma and no further investigation of this agent on this schedule in this disease is recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00874449
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  • 3
    Electronic Resource
    Electronic Resource
    Phase II trial of trimetrexate in untreated advanced gastric carcinoma (1994)
    Springer
    Investigational new drugs 12 (1994), S. 155-157 
    Details
    ISSN: 1573-0646
    Keywords: trimetrexate ; gastric adenocarcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-three evaluable patients with advanced gastric adenocarcinoma were treated with trimetrexate at doses of 8–12 mg/m2 intravenously daily for five days, with cycles repeated every 21 days. One complete response was seen for an overall response rate of 4% (95% confidence interval 0–22%). Hematologie toxicities of grade ≥ 3 were seen in 10/23 patients, and overall any grade 3 or greater toxicity was seen in 14/ 23 patients. Trimetrexate has minimal activity against gastric adenocarcinoma in this study, and no further investigation of this agent at this dose and schedule is recommended in this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00874448
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