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  • 1
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    Cancer. A bull's eye for targeted lung cancer therapy (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-06-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Minna, John D -- Gazdar, Adi F -- Sprang, Stephen R -- Herz, Joachim -- P50CA70907/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2004 Jun 4;304(5676):1458-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. john.minna@utsouthwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15178790" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/drug therapy/genetics/metabolism ; Amino Acid Substitution ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy/*genetics/metabolism ; Controlled Clinical Trials as Topic ; Enzyme Inhibitors/therapeutic use ; Epidermal Growth Factor/metabolism ; *Genes, erbB-1 ; Humans ; Japan ; Ligands ; Lung Neoplasms/*drug therapy/*genetics/metabolism ; *Mutation ; Phosphorylation ; Protein Structure, Tertiary ; Quinazolines/*therapeutic use ; Receptor, Epidermal Growth Factor/*antagonists & ; inhibitors/chemistry/genetics/metabolism ; Sequence Deletion ; Smoking ; Treatment Outcome ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Deuterium magnetic resonance on elongated networks: orientational order versus network structure (1987)
    Springer
    Colloid & polymer science 75 (1987), S. 45-48 
    Details
    ISSN: 1435-1536
    Schlagwort(e): rubber ; polydimethylsiloxane ; deuterium NMR ; orientational order ; trapped entanglements
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Notizen: Abstract The orientational order generated in uniaxially strained (end-linked) polydimethylsiloxane rubbers is investigated as a function of the length of the precursor chains and of the polymer concentration at which the network was formed. The degree of orientational order was measured by means of the deuterium NMR technique performed on labelled network chains. The induced order increases with the density of crosslinking junctions and trapped entanglements. The observed effects are analysed versus the equilibrium swelling degree of the samples, in order to characterize the real network structure with respect to chain segment ordering.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01188357
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 3
    Digitale Medien
    Digitale Medien
    Strain-induced large fluctuations during stress relaxation in polymer melts observed by small-angle neutron scattering. “Lozenges”, “butterflies”, and related theory (1991)
    Springer
    Colloid & polymer science 269 (1991), S. 195-216 
    Details
    ISSN: 1435-1536
    Schlagwort(e): Polymer networks ; polymer melts ; polymer blends ; rubber ; deformation ; small-angle neutron scattering ; dynamics ; relaxation ; polystyrene ; crosslinking ; heterogeneities ; finite extensibility ; entanglements ; demixing ; segregation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Notizen: Abstract We discuss the neutron scattering features of melts containing a fraction of labeled chains, and of rubbers containing a fraction of deuterated paths along several successive elementary chains. Both types of material are studied during relaxation after a fast deformation in very similar conditions. An unusual feature is the shape of the anisotropic scattering as visualized on a bidimensional detector: the isointensity lines have the shape of lozenges. A detailed review of various cases makes this appear as a general feature in SANS scattering from melts and rubbers in a state of partially relaxed deformation. We then describe results for mixtures of small labeled chains inside matrices of large entangled chains or crosslinked matrices: we find another unusual shape of the isointensity levels, called “butterfly”. We propose the lozenges to be a combination of the classical elliptical scattering with a butterfly scattering, which has a main axis orthogonal to the main axis of the ellipses. We discuss in more details the origin of the butterfly effect, by following two tracks: the first is several theories about demixing under strain, including influence of the strain on the enthalpic, elastic, and conformational terms of the free energy of mixing. The second track is the influence of heterogeneities in crosslinked materials. An explanation which would be common to the case of crosslinked and uncrosslinked material remains to be established.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00665493
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 4
    Digitale Medien
    Digitale Medien
    Dynamics of permanent and temporary networks: Small angle neutron scattering measurements and related remarks on the classical models of rubber deformation (1987)
    Springer
    Colloid & polymer science 75 (1987), S. 152-170 
    Details
    ISSN: 1435-1536
    Schlagwort(e): Polymer networks ; rubber de formation ; small angle neutron scattering ; dynamics ; relaxation ; polystyrene ; crosslinking
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Notizen: Abstract We observed the neutron scattering of mixtures of deuterated and normal polystyrene in bulk for samples (strips) undergoing a stress relaxation after a step-strain. Some samples were just melt (i.e. molten at T 〉 Tg=100°C), others were crosslinked and thus some were rubbers at T 〉Tg. The scattering measured at different times elapsed after the step-strain gives access to the dynamics at the submolecular scale (300-10 A). It is compared with the theoretical predictions that one may extract from the classical models. Observed discrepancies are tentatively interpreted following several “remarks” on the topology of the network and the possible mechanisms of deformation at the corresponding scales.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01188369
    Standort Signatur Erwartet Verfügbarkeit
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