ISSN:
1432-1041
Keywords:
oxyphenbutazone
;
inflammation
;
diffusion
;
synovial fluid
;
synovial tissue
;
cerebrospinal fluid
;
joint cartilage
;
tissue level
;
CSF level
;
joint level
;
distribution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The diffusion of oxyphenbutazone into synovial and cerebrospinal fluids and synovium and joint cartilage was investigated in 25 patients receiving short-term treatment. In the synovial fluid, the mean oxyphenbutazone concentration, was 57.1±13.4% of the plasma level, due to its excellent diffusion into the joint cavity. In synovial tissue, the oxyphenbutazone level was higher in patients with severe inflammation than in those with no or little inflammation. Penetration into joint cartilage is less than into synovial tissue. In cerebrospinal fluid the concentration was close to the level of free plasma oxyphenbutazone. The findings show increased diffusion of oxyphenbutazone towards its site of action in inflammation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00544025
Permalink
