ISSN:
1432-1041
Keywords:
kallikrein
;
nephrotic syndrome
;
protease inhibition
;
alpha1-antitrypsin
;
alpha2-macroglobulin
;
inter-alpha-trypsin inhibitor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary An inverse relationship between proteolytic activity in the presence of kallikrein 0.4 IU and urinary alpha1-antitrypsin concentration has been demonstrated. This protease inhibitor can directly inactivate kallikrein activity. The inhibition was abolished by removal of urinary alpha1-antitrypsin by trypsinsepharose treatment. Inhibition could be reversed by addition of purified alpha1-antitrypsin. These effects could not be demonstrated with inter-alpha-trypsin inhibitor or alpha2-macroglobulin. The inhibitory effect of alpha1-antitrypsin on kallikrein activity should be taken into account in studies in which kallikrein activity is estimated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00609628
Permalink
