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  • 1
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    The role of visual experience in the development of columns in cat visual cortex (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-02-07
    Description: The role of experience in the development of the cerebral cortex has long been controversial. Patterned visual experience in the cat begins when the eyes open about a week after birth. Cortical maps for orientation and ocular dominance in the primary visual cortex of cats were found to be present by 2 weeks. Early pattern vision appeared unimportant because these cortical maps developed identically until nearly 3 weeks of age, whether or not the eyes were open. The naive maps were powerfully dominated by the contralateral eye, and experience was needed for responses to the other eye to become strong, a process unlikely to be strictly Hebbian. With continued visual deprivation, responses to both eyes deteriorated, with a time course parallel to the well-known critical period of cortical plasticity. The basic structure of cortical maps is therefore innate, but experience is essential for specific features of these maps, as well as for maintaining the responsiveness and selectivity of cortical neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453000/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453000/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crair, M C -- Gillespie, D C -- Stryker, M P -- EY02874/EY/NEI NIH HHS/ -- EY09760/EY/NEI NIH HHS/ -- R37 EY002874/EY/NEI NIH HHS/ -- R37 EY002874-20/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1998 Jan 23;279(5350):566-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉W. M. Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9438851" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Brain Mapping ; Cats ; Microelectrodes ; *Photic Stimulation ; Vision, Monocular ; *Vision, Ocular ; Visual Cortex/*physiology ; Visual Pathways
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Columnar architecture sculpted by GABA circuits in developing cat visual cortex (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-16
    Description: The mammalian visual cortex is organized into columns. Here, we examine cortical influences upon developing visual afferents in the cat by altering intrinsic gamma-aminobutyric acid (GABA)-mediated inhibition with benzodiazepines. Local enhancement by agonist (diazepam) infusion did not perturb visual responsiveness, but did widen column spacing. An inverse agonist (DMCM) produced the opposite effect. Thus, intracortical inhibitory circuits shape the geometry of incoming thalamic arbors, suggesting that cortical columnar architecture depends on neuronal activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562723/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562723/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hensch, Takao K -- Stryker, Michael P -- R37 EY002874/EY/NEI NIH HHS/ -- R37 EY002874-24S1/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 12;303(5664):1678-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. hensch@postman.riken〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15017001" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbolines/pharmacology ; Cats ; Diazepam/pharmacology ; Dominance, Ocular/*physiology ; Electrophysiology ; GABA-A Receptor Agonists ; Neural Inhibition ; Neurons/*physiology ; Photic Stimulation ; Receptors, GABA-A/physiology ; Synaptic Transmission ; Thalamus/growth & development/physiology ; Vision, Ocular ; Visual Cortex/anatomy & histology/*growth & development/*physiology ; Visual Pathways ; gamma-Aminobutyric Acid/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Local GABA circuit control of experience-dependent plasticity in developing visual cortex (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-11-20
    Description: Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851625/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851625/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hensch, T K -- Fagiolini, M -- Mataga, N -- Stryker, M P -- Baekkeskov, S -- Kash, S F -- R37 EY002874/EY/NEI NIH HHS/ -- R37 EY002874-20/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1998 Nov 20;282(5393):1504-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. hensch@postman.riken.go.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9822384" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diazepam/pharmacology ; GABA Modulators/pharmacology ; Gene Targeting ; Glutamate Decarboxylase/genetics/*metabolism ; Interneurons/*physiology ; Long-Term Potentiation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; *Neuronal Plasticity/drug effects ; Photic Stimulation ; Receptors, GABA-A/metabolism ; Synaptic Transmission ; Visual Cortex/cytology/metabolism/*physiology ; Visual Pathways ; gamma-Aminobutyric Acid/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Ocular dominance plasticity under metabotropic glutamate receptor blockade (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-04-26
    Description: Occluding vision through one eye during a critical period in early life nearly abolishes responses to that eye in visual cortex. This phenomenon is mimicked by long-term depression of synaptic transmission in vitro, which may require metabotropic glutamate receptors (mGluRs) and is age-dependent. Peaks in mGluR expression and glutamate-stimulated phosphoinositide turnover during visual cortical development have been proposed as biochemical bases for the critical period. Pharmacological blockade of mGluRs specifically prevented synapse weakening in mouse visual cortical slices but did not alter kitten ocular dominance plasticity in vivo. Thus, a heightened mGluR response does not account for the critical period in development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hensch, T K -- Stryker, M P -- EY02874/EY/NEI NIH HHS/ -- R01 EY002874/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1996 Apr 26;272(5261):554-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neuroscience Graduate Program, W. M. Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, 94143-0444, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614806" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzoates/*pharmacology ; Cats ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Amino Acid Antagonists/*pharmacology ; Glycine/*analogs & derivatives/pharmacology ; In Vitro Techniques ; Membrane Potentials ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity/drug effects/*physiology ; Photic Stimulation ; Receptors, Metabotropic Glutamate/antagonists & inhibitors/*physiology ; Sensory Deprivation ; Vision, Monocular ; Visual Cortex/drug effects/*physiology ; Visual Pathways
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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