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  • Rodents  (1)
  • Transforming growth factor-β  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Transforming growth factor-β, basement membrane components and heparan sulphate proteoglycans in experimental hepatic schistosomiasis mansoni (1998)
    Springer
    Cell & tissue research 292 (1998), S. 101-106 
    Details
    ISSN: 1432-0878
    Keywords: Key words Fibrosis ; Transforming growth factor-β ; Basement membranes ; Heparan sulphate proteoglycans ; Schistosoma mansoni ; Mouse (Swiss OF1)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  In an attempt to elucidate further the immunopathological pathways that underlie fibrogenesis induced by Schistosoma mansoni, we have studied the distribution of basement membrane compounds, heparan sulphate proteoglycans (HSPG) and the fibrogenic cytokine transforming growth factor (TGF)-β in two models of experimental schistosomiasis mansoni (experimental murine infection and synchronous granulomas induced by injection of egg-antigen-coupled beads into the caecal vein). Deposition of the basement membrane proteins type IV collagen, laminin and entactin in schistosomal granulomas was seen 3 days after the implantation of egg-antigen-coupled beads in the liver and persisted over time (32 days). Up-regulation of the membrane-bound HSPG syndecan-1 was observed in the schistosomal granuloma. These syndecan-1-immunoreactive cells represented a distinct subpopulation of granuloma cells; they were different from both mature, unstimulated B-cells (CD40-positive) and endothelial cells (CD105-positive). Deposition of the matrix HSPG perlecan within the granuloma was most prominent 8–16 days after injection. TGF-β expression was observed in acute (8 weeks) and chronically (13 weeks) infected mice, mainly at the periphery of the schistosomal granuloma and on Kupffer cells in the liver parenchyma. From these observations, we infer that schistosomal fibrosis is composed of various groups of matrix components and that TGF-β, which is secreted by granuloma cells, is one of the fibrogenic mediators in schistosomal fibrogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410051039
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental infections of laboratory rodents with recently isolated stocks ofTrypanosoma brucei gambiense (1981)
    Springer
    Parasitology research 64 (1981), S. 187-193 
    Details
    ISSN: 1432-1955
    Keywords: T. b. gambiense ; Rodents ; Histopathology ; Brain ; Heart ; Liver ; Spleen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Histopathological findings on brain, heart, liver, and spleen of albino rats and white mice, infected with different stocks ofTrypanosoma brucei gambiense of human origin are presented. Classical brain lesions, including chronic inflammation of the choroid plexuses, were observed in all infected animals, the severity of which increased with the chronicity of the disease. Parasite stocks which gave rise to a less acute course of the disease more often induced myocarditis, while brain lesions were less pronounced, suggesting that virulence of the parasites is more closely related to the advent of myocarditis than to the appearance of brain lesions. Liver lesions were not obvious. In spleens, a variable and often very pronounced degree of lymphoid hyperplasia was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00930495
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    Paper (German National Licenses)
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