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Acitretin (Neotigason®) (1992)

Bouvy, M. L. ; Sturkenboom, M. C. J. M. ; Cornel, M. C. ; [et al.]

Springer

Pharmacy world & science 14 (1992), S. 33-37

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ISSN: 1573-739X

Keywords: Acitretin ; Etretinate ; Metabolism ; Pharmacokinetics ; Retinoids ; Teratogens

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Acitretin was introduced as a replacement for etretinate, the ethyl ester of acitretin. Acitretin is eliminated at a much faster rate than etretinate. Although both drugs are teratogens, the replacement was important especially as it allowed for a much shorter post-medication period in which pregnancy should be precluded. Recent findings showed the presence of etretinate in the plasma of acitretin-treated patients. This article gives a review of known metabolic pathways of the retinoids and tries to elucidate the possible conversion of acitretin into etretinate after acitretin ingestion.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01980479

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