ISSN:
1573-739X
Schlagwort(e):
Acitretin
;
Etretinate
;
Metabolism
;
Pharmacokinetics
;
Retinoids
;
Teratogens
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract Acitretin was introduced as a replacement for etretinate, the ethyl ester of acitretin. Acitretin is eliminated at a much faster rate than etretinate. Although both drugs are teratogens, the replacement was important especially as it allowed for a much shorter post-medication period in which pregnancy should be precluded. Recent findings showed the presence of etretinate in the plasma of acitretin-treated patients. This article gives a review of known metabolic pathways of the retinoids and tries to elucidate the possible conversion of acitretin into etretinate after acitretin ingestion.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01980479
Permalink
