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  • Dynamicin vitro testing of human muscle  (2)
  • Surelease  (2)
  • Springer  (4)
  • American Chemical Society
  • American Chemical Society (ACS)
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  • Springer  (4)
  • American Chemical Society
  • American Chemical Society (ACS)
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  • 1
    Electronic Resource
    Electronic Resource
    Tensile Properties of Free Films Cast from Aqueous Ethylcellulose Dispersions (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 810-815 
    Details
    ISSN: 1573-904X
    Keywords: ethylcellulose ; Surelease ; dibutyl sebacate ; glyceryl tricaprylate/caprate ; cast films ; mechanical properties ; tensile strength ; work of failure ; elastic modulus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Free films of two commercially available formulations of aqueous ethylcellulose dispersion differing only in plasticizer content (Surelease/E-7-7050 without silica and E-7-7060 containing dibutyl sebacate and glyceryl tricaprylate/caprate as plasticizers, respectively) were cast and coalesced at temperatures ranging between 30 and 70°C. Mechanical properties of these films were measured using tensile stress analysis. Three mechanical parameters, namely, tensile strength, work of failure, and elastic modulus, were computed from the load-time profiles of these films. The results showed that the tensile strength and elastic modulus values of the films cast from both formulations increased with the corresponding increase in coalescence temperature up to 60°C, beyond which no significant differences were observed. In the case of work of failure, however, the difference between the two formulations was observed above 60°C. The films cast from Surelease/E-7-7050 formulation without silica (dibutyl sebacate as the plasticizer) were relatively softer than those from Surelease/E-7-7060 formulation (glyceryl tricaprylate/caprate as the plasticizer). At coalescence temperatures above 50°C, the films cast from both formulations exhibited temperature-dependent plastic deformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018992607245
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  • 2
    Electronic Resource
    Electronic Resource
    Aqueous Ethylcellulose Dispersion of Ethylcellulose. I. Evaluation of Coating Process Variables (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 525-534 
    Details
    ISSN: 1573-904X
    Keywords: factorial experimental design ; response surface methodology (RSM) ; ethylcellulose ; Surelease ; ibuprofen ; fluid-bed coating ; latex film ; microindentation hardness ; zero-order drug release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Formulation and process variables play an important role in the film-forming properties of coating polymers. Three selected independent coating process variables, namely, percent solids content in the coating polymeric dispersion, inlet-air temperature, and spray rate of the polymeric dispersion, were investigated in this study to determine their effect on the performance characteristics of tablets coated with a plasticized aqueous ethylcellulose dispersion (Surelease) in a fluid-bed equipment. Response surface methodology (RSM) was utilized to study the complex relationship between these process variables and selected response variables. Three response variables were considered, namely, rate of drug release from the “untreated” coated tablets and the “thermal-treated” coated tablets and microindentation hardness of the untreated coated tablets. A 12-point factorial experimental design was utilized, and three-dimensional (3-D) response surface plots were generated using a second-order polynomial model. The model provided information needed to predict optimal process conditions. Drug release from the coated tablets followed zero-order kinetics. Inlet-air temperature was found to be the most critical process variable for all the three response variables studied. A correlation was observed between the drug release rate and the microindentation hardness of the applied polymeric coat in the case of untreated coated tablets. The 3-D response surface plots indicated that lower rates of drug release from the coated tablets may be obtained by using high inlet-air temperature and low spray rate of the polymeric dispersion during coating.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018989717297
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  • 3
    Electronic Resource
    Electronic Resource
    Developments in apparatus for dynamicin vitro testing of human muscle (1974)
    Springer
    Medical & biological engineering & computing 12 (1974), S. 647-653 
    Details
    ISSN: 1741-0444
    Keywords: Dynamicin vitro testing of human muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Des instruments servant à améliorer la validité des données de tests dynamiques obtenues sur des spécimens de muscles d'humains ont été développés. Dans la première partie de cet article, on donne l'acquis et on décrit un appareil permettant de monter et de fixer un petit spécimen de muscle afin de le rendre disponible aux expériences en moins d'une minute. La seconde partie décrit un instrument de contrôle de durée et de mise en séquence, capable de contrôler les stimulations mécaniques et électriques infligées au spécimen. Les déplacements mécaniques sont contrôlés par un type de servo mécanisme pouvant être entraîné par un magnétophone à fréquence modulée.
    Abstract: Zusammenfassung Zur Verbesserung der Bedeutung dynamischer Testdaten aus menschlichen Muskelproben wurden gewisse Apparate und Instrumente entwickelt. Im ersten Teil dieser Arbeit wird die Vorgeschichte aufgezeigt und ein Apparat zum Einspannen und Aufspannen beschrieben, mit dem kleine Muskelproben in weniger als einer Minute für die Prüfung vorbereitet werden können. Der zweite Teil beschreibt einen neuen Impulsgeber und eine Folgeschaltung zur Regulierung der elektrischen und mechanischen Stimulationen, die auf die Probe angewandt werden. Die mechanische Verschiebung wird durch eine Art Servomechanismus gesteuert, der über ein FM-Bandgerät angetrieben wird.
    Notes: Abstract Some apparatus and instrumentation have been developed for improving the relevance of dynamic test data obtained from human muscle specimens. In the first part of this paper the background is given and a special clamping and mounting arrangement is described which allows a small specimen to be made ready for test in less than a minute. The second part describes a new timing and sequencing instrument for regulating the electrical and mechanical stimulations applied to the specimen. The mechanical displacements are controlled by a type of servomechanism which can be driven from an f.m. tape recorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02477227
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  • 4
    Electronic Resource
    Electronic Resource
    Developments in apparatus for dynamicin vitro testing of human muscle (1974)
    Springer
    Medical & biological engineering & computing 12 (1974), S. 654-663 
    Details
    ISSN: 1741-0444
    Keywords: Dynamicin vitro testing of human muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire La première partie de cet article (Fay et al. 1974) présente l'acquis des travaux et suggère la conception d'un appareil permettant de fixer et de stimuler un petit spécimen de muscle dans un entourage contrôté. L'appareil décrit comprend une commande électrique et un transduceur à la fois de force et de déplacement. Cette partie concluante décrit le contrôle et la mise en séquence du système.
    Abstract: Zusammenfassung Der erste Teil dieser Arbeit (vonFay u.a., 1974) zeigte die Vorgeschichte der Arbeitet auf und stellte eine Apparatekonstruktion zum Einspannen und Stimulieren kleiner Muskelproben in kontrollierter Umgebung vor. Das beschriebene Gerät hatte eine elektrische Betätigung sowie Meßwandler fûr Kraft und Verlagerung. Dieser abschließende Teil zeigt, wie das System geschalten und in Folge geschaltet wird.
    Notes: Abstract The first part of this paper (Fay et al., 1974) presented the background to the work and put forward a design for apparatus for clamping and stimulating a small muscle specimen in a controlled environment. The apparatus described included an electromagnetic actuator and both force and displacement transducers. This concluding part shows how the system is controlled and sequenced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02477228
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