Publication Date:
1978-07-14
Description:
3-Methylindole, a ruminal fermentation product of tryptophan, induces acute pulmonary edema and emphysema in cattle, and 3-methylindole is present in the ruminal fluid and blood of cows with a natually occurring form of this disease. Monensin, a polyether antibiotic and widely used feed additive for beef cattle, prevented tryptophan-induced acute bovine pulmonary edema and emphysema. Monensin acted by reducing the ruminal conversion of L-tryptophan to 3-methylindole both in vitro and in vivo. Lasalocid, also a polyether antibiotic, showed similar effects in vitro. These results provide a promising approach to prevention of this major respiratory disease of cattle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hammond, A C -- Carlson, J R -- Breeze, R G -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):153-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663643" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cattle
;
Furans/*therapeutic use
;
Lasalocid/therapeutic use
;
Monensin/pharmacology/*therapeutic use
;
Pneumonia, Atypical Interstitial, of Cattle/*prevention & control
;
Rumen/metabolism
;
Skatole/metabolism
;
Tryptophan/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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