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    Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-28
    Description: Stem cells are maintained in the niche by intercellular interactions and signaling networks. In this work, we study extracellular signals required for maintenance of the root stem cell niche in higher plants. We identify a family of functionally redundant homologous peptides that are secreted, tyrosine-sulfated, and expressed mainly in the stem cell area and the innermost layer of central columella cells. We name these peptides root meristem growth factors (RGFs). RGFs are required for maintenance of the root stem cell niche and transit amplifying cell proliferation in Arabidopsis. RGF1 defines expression levels and patterns of the stem cell transcription factor PLETHORA, mainly at the posttranscriptional level. The RGFs function independently of the auxin pathway. These peptide signals play a crucial role in postembryonic root development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuzaki, Yo -- Ogawa-Ohnishi, Mari -- Mori, Ayaka -- Matsubayashi, Yoshikatsu -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):1065-7. doi: 10.1126/science.1191132.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School of Bio-Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20798316" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/cytology/genetics/growth & development/*physiology ; Arabidopsis Proteins/genetics/*metabolism/secretion ; Cell Proliferation ; Gene Expression Regulation, Plant ; Genes, Plant ; Indoleacetic Acids/metabolism ; Meristem/cytology/growth & development/physiology ; Peptides/genetics/*metabolism/secretion ; Phenotype ; Plant Growth Regulators/genetics/*metabolism ; Plant Roots/*cytology/growth & development/physiology ; Plants, Genetically Modified ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Stem Cell Niche/*physiology ; Stem Cells/cytology/*physiology ; Sulfotransferases/genetics/metabolism ; Transcription Factors/genetics/metabolism ; Up-Regulation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    "Stemness": transcriptional profiling of embryonic and adult stem cells (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-14
    Description: The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to define a genetic program for stem cells. A total of 216 genes are enriched in all three types of stem cells, and several of these genes are clustered in the genome. When compared to differentiated cell types, stem cells express a significantly higher number of genes (represented by expressed sequence tags) whose functions are unknown. Embryonic and neural stem cells have many similarities at the transcriptional level. These results provide a foundation for a more detailed understanding of stem cell biology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramalho-Santos, Miguel -- Yoon, Soonsang -- Matsuzaki, Yumi -- Mulligan, Richard C -- Melton, Douglas A -- P60 HL54785/HL/NHLBI NIH HHS/ -- R24 DK56947/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 18;298(5593):597-600. Epub 2002 Sep 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology and Howard Hughes Medical Institute (HHMI), Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228720" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/genetics/metabolism ; Animals ; Bone Marrow Cells/physiology ; Cell Differentiation ; DNA Helicases/genetics/metabolism ; Embryo, Mammalian/*cytology ; Expressed Sequence Tags ; *Gene Expression ; *Gene Expression Profiling ; Gene Expression Regulation ; Hematopoietic Stem Cells/*physiology ; Lateral Ventricles/cytology ; Mice ; Mice, Inbred C57BL ; Neurons/*cytology ; Oligonucleotide Array Sequence Analysis ; Oxidative Stress ; Reproducibility of Results ; Signal Transduction ; Stem Cells/*physiology ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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