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  • 1
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    Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-07
    Description: To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familial clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dehal, P -- Predki, P -- Olsen, A S -- Kobayashi, A -- Folta, P -- Lucas, S -- Land, M -- Terry, A -- Ecale Zhou, C L -- Rash, S -- Zhang, Q -- Gordon, L -- Kim, J -- Elkin, C -- Pollard, M J -- Richardson, P -- Rokhsar, D -- Uberbacher, E -- Hawkins, T -- Branscomb, E -- Stubbs, L -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):104-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉DOE Joint Genome Institute, Walnut Creek, CA 94598, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441184" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Breakage/genetics ; Chromosomes, Human, Pair 19/*genetics ; Conserved Sequence/*genetics ; Contig Mapping ; DNA, Satellite/genetics ; *Evolution, Molecular ; Exons/genetics ; Expressed Sequence Tags ; Gene Dosage ; Gene Order/genetics ; Genetic Linkage/genetics ; Genome ; Humans ; Long Interspersed Nucleotide Elements/genetics ; Mice ; Multigene Family/genetics ; Open Reading Frames/genetics ; Phylogeny ; Sequence Alignment ; Sequence Analysis, DNA ; Short Interspersed Nucleotide Elements/genetics ; Terminal Repeat Sequences/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Comparative metagenomics of microbial communities (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-23
    Description: The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tringe, Susannah Green -- von Mering, Christian -- Kobayashi, Arthur -- Salamov, Asaf A -- Chen, Kevin -- Chang, Hwai W -- Podar, Mircea -- Short, Jay M -- Mathur, Eric J -- Detter, John C -- Bork, Peer -- Hugenholtz, Philip -- Rubin, Edward M -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):554-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Energy (DOE) Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845853" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaea/classification/genetics/metabolism ; Bacteria/classification/*genetics/metabolism ; Bacterial Proteins/genetics/metabolism ; Biodiversity ; Biofilms ; Bone and Bones/microbiology ; Computational Biology ; *Ecosystem ; Energy Metabolism ; Eukaryotic Cells/metabolism ; Gene Library ; Genes ; Genes, Bacterial ; *Genome ; Genome, Bacterial ; *Genomics ; Molecular Sequence Data ; Operon ; Phylogeny ; Polymerase Chain Reaction ; Proteins/genetics/metabolism ; Proteome ; Seawater/*microbiology ; Sequence Analysis, DNA ; *Soil Microbiology ; Whales/*microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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