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  • Chemistry  (2)
  • Saralasin/pharmacology  (1)
  • bedrest  (1)
  • 1980-1984  (4)
  • 1935-1939
  • 1
    Digitale Medien
    Digitale Medien
    Effect of posture and sleep on pharmacokinetics (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 175-183 
    Details
    ISSN: 1432-1041
    Schlagwort(e): amoxycillin ; pharmacokinetics ; bedrest ; sleep ; ambulation ; renal clearance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of amoxycillin in normal male volunteers was studied during the states of bedrest, sleep and ambulation. The absorption and disposition of amoxycillin in ambulatory subjects was found to be comparable to that reported previously by other workers. Serum amoxycillin concentrations were found to be significantly greater during ambulation than during bedrest and sleep. The difference in serum levels resulted from an increased apparent total serum clearance and amoxycillin renal clearance during bedrest and sleep compared to ambulation. No significant differences in the clearance was found between the states of bedrest and sleep. The change in renal clearance of amoxycillin during ambulation was attributed to a diminished renal blood flow. Although the terminal half-life of amoxycillin did not differ significantly, the apparent volume of distribution appears to be much greater during bedrest and sleep than during ambulation. This difference could be explained pharmacokinetically using a two compartment model. No significant difference was found between the rates of absorption of amoxycillin as reflected by the lag time and time to peak serum amoxycillin. The actual values for these parameters would suggest, however, that the absorption of amoxycillin is faster during ambulation than in bedrest and that the absorption rate during sleep is slowest. The clinical implications of the effect of posture and sleep on the pharmacokinetics of amoxycillin are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561587
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Batch polymerization of styrene-optimal temperature historiesThis paper was presented at the 1980 Annual Meeting, American Institute of Chemical Engineers, Chicago, III. (November 1980). (1982)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 22 (1982), S. 1-8 
    Details
    ISSN: 0032-3888
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Optimal temperature histories for the batch thermal polymerization of styrene are determined using Pontryagin's maximum principle. The theoretical predictions are compared with experimental measurements of conversion and molecular weight distribution. The excellent agreement suggests policy improvements in batch radical chain growth polymerizations.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pen.760220102
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Helix-coil stability constants for the naturally occurring amino acids in water. XXI. Glutamine parameters from random poly(hydroxypropylglutamine-co-L-glutamine) and poly(hydroxybutylglutamine-co-L-glutamine) (1982)
    New York : Wiley-Blackwell
    Biopolymers 21 (1982), S. 51-77 
    Details
    ISSN: 0006-3525
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Water-soluble, random copolymers containing L-glutamine and either N5-(3-hydroxypropyl)-L-glutamine or N5-(4-hydroxybutyl)-L-glutamine were synthesized, fractionated, and characterized. The thermally induced helix-coil transitions of these copolymers were studied in water. A short-range interaction theory was used to deduce the Zimm-Bragg parameters σ and s for the helix-coil transition in poly(L-glutamine) in water from an analysis of the melting curves of the copolymers in the manner described in earlier papers. The computed values of s indicate that L-glutamine is helix-indifferent at low temperature and a helix-destabilizing residue at high temperature in water. At all temperatures in the range of 0-70°C, the glutamine residue promotes helix-coil boundaries since the computed value of σ is large.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bip.360210106
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Unbekannt
    Sodium appetite in sheep induced by cerebral ventricular infusion of angiotensin: comparison with sodium deficiency (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-09
    Beschreibung: Intraventricular administration of supraphysiological amounts of renin, nerve growth factor preparation, or angiotensin II greatly increased the consumption of water and hypertonic sodium bicarbonate solution by sheep. These effects were antagonized by intraventricular administration of drugs that prevent the formation of angiotensin II or block its receptors. The fact that these angiotensin-blocking drugs did not change the sodium intake of sodium-deficient sheep challenges the idea that central angiotensin action is involved in sodium appetite due to a deficiency.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coghlan, J P -- Considine, P J -- Denton, D A -- Fei, D T -- Leksell, L G -- McKinley, M J -- Muller, A F -- Tarjan, E -- Weisinger, R S -- Bradshaw, R A -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):195-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169149" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Angiotensin II/*pharmacology ; Animals ; Appetite/*drug effects ; Drinking Behavior/drug effects ; Injections, Intraventricular ; Nerve Growth Factors/pharmacology ; Renin/pharmacology ; Saralasin/pharmacology ; Sheep ; Sodium/deficiency/*metabolism ; Teprotide/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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