ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Water-soluble, random copolymers containing L-glutamine and either N5-(3-hydroxypropyl)-L-glutamine or N5-(4-hydroxybutyl)-L-glutamine were synthesized, fractionated, and characterized. The thermally induced helix-coil transitions of these copolymers were studied in water. A short-range interaction theory was used to deduce the Zimm-Bragg parameters σ and s for the helix-coil transition in poly(L-glutamine) in water from an analysis of the melting curves of the copolymers in the manner described in earlier papers. The computed values of s indicate that L-glutamine is helix-indifferent at low temperature and a helix-destabilizing residue at high temperature in water. At all temperatures in the range of 0-70°C, the glutamine residue promotes helix-coil boundaries since the computed value of σ is large.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.360210106