ISSN:
1573-4951
Keywords:
Distance geometry
;
Receptor mapping
;
QSAR
;
Receptor interaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The method known as ‘distance geometry approach’ for receptor mapping procedures is discussed. In this method a ligand binding to a certain receptor is considered as a collection of ligand points. Binding sites of the receptor are either ‘empty’ or ‘filled’ site points; a ligand point might bind to an empty site point; filled site points indicate that at that point no binding is possible. A binding mode of a ligand is a list of which ligand points coincide with which empty binding sites. The applicability of the method for QSAR studies is discussed; as examples are mentioned the dihydrofolate reductase, β1- and β2-receptors. Finally, some ideas on future developments in receptor mapping are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01677048
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