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  • 1
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    Ancient pathways programmed by small RNAs (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-23
    Description: Double-stranded RNA can now be used in a wide variety of eukaryotes to suppress the expression of virtually any gene, allowing the rapid analysis of that gene's function, a technique known as RNA interference. But how cells use the information in double-stranded RNA to suppress gene expression and why they contain the machinery to do so remain the subjects of intense scrutiny. Current evidence suggests that RNA interference and other "RNA silencing" phenomena reflect an elaborate cellular apparatus that eliminates abundant but defective messenger RNAs and defends against molecular parasites such as transposons and viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zamore, Phillip D -- New York, N.Y. -- Science. 2002 May 17;296(5571):1265-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Lazare Research Building, Room 825, 364 Plantation Street, Worcester, MA 01605, USA. phillip.zamore@umassmed.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016303" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA Transposable Elements ; Endoribonucleases/metabolism ; *Gene Silencing ; Humans ; Plant Diseases ; Plants/genetics ; RNA Replicase/metabolism ; RNA, Antisense/genetics/metabolism ; RNA, Double-Stranded/genetics/*metabolism ; RNA, Messenger/genetics/metabolism ; RNA, Plant/genetics/metabolism ; RNA, Small Interfering ; RNA, Untranslated/genetics/*metabolism ; Ribonuclease III ; Ribonucleoproteins/metabolism ; Transcription, Genetic ; Transgenes ; Virus Diseases/prevention & control ; Virus Physiological Phenomena
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-14
    Description: The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let-7 stRNA. Targeted destruction in cultured human cells of the messenger RNA encoding the enzyme Dicer, which acts in the RNA interference pathway, leads to accumulation of the let-7 precursor. Thus, the RNA interference and stRNA pathways intersect. Both pathways require the RNA-processing enzyme Dicer to produce the active small-RNA component that represses gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hutvagner, G -- McLachlan, J -- Pasquinelli, A E -- Balint, E -- Tuschl, T -- Zamore, P D -- GM62862-01/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Aug 3;293(5531):834-8. Epub 2001 Jul 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11452083" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blotting, Northern ; Drosophila melanogaster ; Endoribonucleases/genetics/*metabolism ; *Gene Expression Regulation, Developmental ; HeLa Cells ; Humans ; Nucleic Acid Conformation ; Protein Structure, Tertiary ; RNA Precursors/*metabolism ; RNA Processing, Post-Transcriptional ; RNA, Double-Stranded/*metabolism ; RNA, Helminth/chemistry/genetics/*metabolism ; RNA, Messenger/genetics/metabolism ; Ribonuclease III ; Transcription, Genetic ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A distinct small RNA pathway silences selfish genetic elements in the germline (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-07-01
    Description: In the Drosophila germline, repeat-associated small interfering RNAs (rasiRNAs) ensure genomic stability by silencing endogenous selfish genetic elements such as retrotransposons and repetitive sequences. Whereas small interfering RNAs (siRNAs) derive from both the sense and antisense strands of their double-stranded RNA precursors, rasiRNAs arise mainly from the antisense strand. rasiRNA production appears not to require Dicer-1, which makes microRNAs (miRNAs), or Dicer-2, which makes siRNAs, and rasiRNAs lack the 2',3' hydroxy termini characteristic of animal siRNA and miRNA. Unlike siRNAs and miRNAs, rasiRNAs function through the Piwi, rather than the Ago, Argonaute protein subfamily. Our data suggest that rasiRNAs protect the fly germline through a silencing mechanism distinct from both the miRNA and RNA interference pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vagin, Vasily V -- Sigova, Alla -- Li, Chengjian -- Seitz, Herve -- Gvozdev, Vladimir -- Zamore, Phillip D -- GM62862/GM/NIGMS NIH HHS/ -- GM65236/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Jul 21;313(5785):320-4. Epub 2006 Jun 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16809489" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Argonaute Proteins ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/*genetics/metabolism ; Female ; Germ Cells/*physiology ; Male ; Mutation ; Oligonucleotide Array Sequence Analysis ; Ovary/cytology ; Peptide Initiation Factors/genetics/metabolism ; Periodic Acid/pharmacology ; Phosphates/analysis ; Proteins/genetics/metabolism ; *RNA Interference ; RNA, Antisense/chemistry/*genetics/metabolism ; RNA, Messenger/genetics/metabolism ; RNA, Small Interfering/chemistry/*genetics/metabolism ; RNA-Induced Silencing Complex ; Repetitive Sequences, Nucleic Acid ; Retroelements ; Terminal Repeat Sequences ; Testis/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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