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  • 1
    Electronic Resource
    Electronic Resource
    Stages of emerging life —Five principles of early organization (1982)
    Springer
    Journal of molecular evolution 19 (1982), S. 47-61 
    Details
    ISSN: 1432-1432
    Keywords: Prebiotic evolution ; Polynucleotide replication ; Quasispecies ; Hypercycles ; Compartmentalization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Five principles underly the evolution of the genetic language: formation of stereoregular heteropolymers, selection through self-replication, evolution of quasispecies towards optimal structures, regulated cooperation between competitors through catalytic hypercycles and evaluation of translation products through compartmentalization. These principles are formulated and illustrated by means of experimental results
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02100223
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  • 2
    Electronic Resource
    Electronic Resource
    RNA multi-structure landscapes (1993)
    Springer
    European biophysics journal 22 (1993), S. 13-24 
    Details
    ISSN: 1432-1017
    Keywords: Fitness landscapes ; Partition function ; Quasispecies ; RNA secondary structures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Statistical properties of RNA folding landscapes obtained by the partition function algorithm (McCaskill 1990) are investigated in detail. The pair correlation of free energies as a function of the Hamming distance is used as a measure for the ruggedness of the landscape. The calculation of the partition function contains information about the entire ensemble of secondary structures as a function of temperature and opens the door to all quantities of thermodynamic interest, in contrast with the conventional minimal free energy approach. A metric distance of structure ensembles is introduced and pair correlations at the level of the structures themselves are computed. Just as with landscapes based on most stable secondary structure prediction, the landscapes defined on the full biophysical GCAU alphabet are much smoother than the landscapes restricted to pure GC sequences and the correlation lengths are almost constant fractions of the chain lengths. Correlation functions for multi-structure landscapes exhibit an increased correlation length, especially near the melting temperature. However, the main effect on evolution is rather an effective increase in sampling for finite populations where each sequence explores multiple structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205808
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  • 3
    Electronic Resource
    Electronic Resource
    Competition and cooperation in catalytic selfreplication (1981)
    Springer
    Journal of mathematical biology 11 (1981), S. 155-168 
    Details
    ISSN: 1432-1416
    Keywords: Catalytic selfreplication ; Concentration simplex ; Dynamical systems ; Flow reactor ; Hypercycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract It is shown that in a flow reactor, hypercyclic coupling of self-reproducing macromolecular species leads to cooperation, i.e. none of the concentrations will vanish. On the other hand, autocatalytic selfreproducing macromolecules usually compete, and the number of surving species increases with the total concentration. Both results are proved under very general assumptions concerning the growth rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275439
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