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  • 1
    Electronic Resource
    Electronic Resource
    The track structures of ionizing particles and their application to radiation biophysics (1999)
    Springer
    Radiation and environmental biophysics 38 (1999), S. 175-184 
    Details
    ISSN: 1432-2099
    Keywords: Key words Alpha particle ; Deuteron ; Proton ; Biophysical modeling ; Radiation quality influence ; Bacillus subtilis ; DNA density ; Monte Carlo calculations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract  A new approach to the interpretation of the effects of radiation on cells is described, in which sample particle tracks are constructed using a Monte Carlo computer program and the exposure of cellular targets to these tracks is simulated using a second program known as BIOPHYS. Data on the shapes and DNA contents of the cell nuclei are obtained from the literature. It is assumed that the sensitive material is DNA, and that the target is divided into cubes of approximately 2 nm (the diameter of the DNA helix) per side; the numbers of these cubes containing different numbers of ionizations are derived. Two different methods of analysing the output of BIOPHYS are described. In the first, it is assumed that lethality is caused by the occurrence of a number of ionizations equal to or greater than a certain threshold in one cube; in the second method, it is assumed that only two ionizations are required, in different parts of the cube, but that only some fraction of the cube is sensitive. These models have been applied to the interpretation of the variation of radiosensitivity with a linear energy transfer (LET) of spores of Bacillus subtilis exposed wet and dry, and good fits to the published experimental data were obtained using both models. Fits to experimental data for a range of other cell lines will be presented in a second paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004110050153
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  • 2
    Electronic Resource
    Electronic Resource
    The track structures of ionizing particles and their application to radiation biophysics (1999)
    Springer
    Radiation and environmental biophysics 38 (1999), S. 249-259 
    Details
    ISSN: 1432-2099
    Keywords: Key words Alpha-particle ; Deuteron ; Proton ; Biophysical modelling ; Radiosensitivity ; Bacillus subtilis ; Haploid yeast ; Human diploid fibroblasts ; DNA repair systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract  Using knowledge of the track structure generated by ionizing particles together with details of the organisms being irradiated, the application of a new analytical method to two biophysical models to explain the inactivation of cells by radiation has been developed. It is shown that both models are equally successful in predicting experimental results and that good agreement is found with the data for single-strand phage, Bacillus subtilis spores, various strains of Escherichia coli, haploid and diploid yeast, and human diploid fibroblasts. The only significant discrepancy arose with T1-phage, for which a tentative explanation is offered. The differences in inherent radiosensitivity between organisms, after allowance is made for differences in target size, are attributed to differences in enzymatic repair systems and in the packing of the DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004110050165
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    Paper (German National Licenses)
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