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  • Organic Chemistry  (3)
  • Polymer and Materials Science  (3)
  • *Action Potentials  (1)
  • 1980-1984  (7)
  • 1
    Electronic Resource
    Electronic Resource
    Asymmetrische Totalsynthese von 19-Nor-Steroiden mit photochemischer Schlüsselreaktion: Enantiomerenreine Zielverbindungen (1982)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1982 (1982), S. 1999-2040 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Asymmetric Total Synthesis of 19-Nor-Steroids via a Photochemical Key Reaction: Enantiomerically Pure Target CompoundsA total synthesis of the enantiomerically pure 19-nor-steroids estrone (1a), 19-norandrost-4-en-3,17-dione (2a), estradiol-17β (3a), and 19-nortestosterone (4a) is described. It follows the A + D→AD→ABCD sequence, proceeds via a kinetically unstable o-quinodimethane derivative obtained in a light induced reaction, and employs the chiral synthetic building block dimethyl (R)-2-vinyl-1,1-cyclopropanedicarboxylate (12b). The latter is easily accessible by an asymmetry inducing ScN′ reaction. During the synthetic procedure it is isolated enantiomerically pure. The analytic procedure reveals that 12b is formed with an optical purity or an enantiomeric excess, respectively, of 95%.
    Notes: Eine Totalsynthese der enantiomerenreinen 19-Nor-Steroide Östron (1a), 19-Norandrost-4-en-3,17-dion (2a), östradiol-17β (3a) und 19-Nortestosteron (4a) wird beschrieben. Sie folgt dem A + D→AD→ABCD-Aufbauprinzip, durchläuft ein lichtinduziertes, kinetisch instabiles o-Chinodimethan-Derivat und verwendet den chiralen Synthesebaustein (R)-2-Vinyl-1,1-cyclopropan-dicarbonsäure-dimethylester (12b). 12b ist durch eine Asymmetrie induzierende ScN′-Reaktion (s. Abb. 2) bequem zugänglich. Bei der Synthese fällt 12b enantiomerenrein an. Das analytische Procedere offenbart, daß 12b mit einer optischen Reinheit oder mit einem Enantiomeren-überschuß jeweils von 95% zustande kommt.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198219821109
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  • 2
    Electronic Resource
    Electronic Resource
    Novel Rearrangement of 1,2:4,8-Diepoxy-p-menthane (1983)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1983 (1983), S. 1446-1447 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Neue Umlagerung von 1,2:4,8-Diepoxy-p-menthanErhitzen von 1,2:4,8-Diepoxy-p-methan (1) mit Aluminiumoxid in Toluol induziert eine Fragmentierung zum 6-Ethenyl-5,6-dihydro-2,2,6-trimethyl-2H-pyran-3(4H)-on (2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198319830817
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  • 3
    Electronic Resource
    Electronic Resource
    Hochselektive Totalsynthese von 19-Nor-Steroiden mit photochemischer Schlüsselreaktion: Racemische Zielverbindungen1,4) (1981)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1981 (1981), S. 2335-2371 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Highly Selective Total Synthesis of 19-Nor-Steroids via a Photochemical Key Reaction: Racemic Target Compounds1,4)Ring A and ring D building blocks 17b and rac-15, easily available from m-cresyl methyl ether (19a) or (E)-1,4-dibromo-2-butene (13b) and methyl malonate (14a), respectively, react by Michael addition affording the key compound rac-9a. The latter compound by successive photoenolization, intramolecular Diels/Alder reaction, and dehydration furnishes the pretarget compounds rac-5 and rac-6. From here the 19-norsteroids rac-estrone (rac-1a), rac-19-norandrost-4-ene-3,17-dione (rac-2a), rac-estradiol-17β (rac-3a), and rac-19-nortestosterone (rac-4a) are optionally accessible (cf. schemes 1 and 2 as well as tables 3 and 4).
    Notes: Die Ring A- und Ring D-Bausteine 17b und rac-15, die bequem aus m-Kresolmethylether (19a) sowie (E)-1,4-Dibrom-2-buten (13b) und Malonsäure-dimethylester (14a) zugänglich sind, fügen sich in einer Michael-Addition zur Schlüsselverbindung rac-9a zusammen. Letztere reagiert nacheinander durch Photoenolisierung, intramolekulare Diels/Alder-Reaktion und Dehydratisierung zu den Präzielverbindungen rac-5 und rac-6. Von hier aus erhält man wahlweise die 19-Nor-Steroide rac-Östron (ra-1a), rac-19-Norandrost-4-en-3,17-dion (rac-2a), rac-Östradiol-17β (rac-3a) und rac-19-Nortestosteron (rac-4a) (s. Schemata 1 und 2 sowie Tab. 3 und 4).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198119811220
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  • 4
    Electronic Resource
    Electronic Resource
    Hydroxyl-modified epoxy resins: Some technical and analytical aspectsDedicated to Professor Dr. H. Batzer in honour of his 60th birthday (1980)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 181 (1980), S. 1-17 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The modification of epoxy resins by reactions involving their hydroxyl groups is described. For example, reactions with enol ethers, acrylonitrile, ethyl acetoacetate and certain other carboxylic esters, or triethyl orthoformate, gave products which had reduced reactivities towards various hardeners, and which therefore gave lower peak temperatures on cure and/or longer usable lives. Suitable modification of epoxy resins with various other reagents(certain acid anhydrides, epichlorohydrin, or N-hydroxymethylacrylamide) introduces additional useful functional groups. The uses of a diisocyanate and of α-naphthyl isocyanate to modify epoxy resins or their mixtures prior to GPC analysis are also mentioned.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1980.021810101
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Berechnung des Druckverlustes in Rohren bei Schlammförderung (1984)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 56 (1984), S. 853-855 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330561109
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  • 6
    Electronic Resource
    Electronic Resource
    Zum Einfluß von Oberflächenverunreinigungen auf den Ladungsabbau bei FEP-Elektreten (1982)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 33 (1982), S. 9-13 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The influence of surface contaminations on isothermal charge decay of electrets of (tetrafluoroethylene-hexafluoropropylene) copolymer was investigated. Carefully rinsed samples showed increased charge stability in comparison with not treated or open stored samples. The results are explained by the partial destruction of the isolating properties of FEP by dust particles.
    Notes: Der Einfluß von Oberflächenverunreinigungen auf den isothermen Ladungsabbau bei Elektreten aus Tetrafluorethylen-Hexafluorpropylen-Copolymer (FEP) wird untersucht. An sorgfältig gespülten Proben ist eine deutliche Erhöhung der Ladungsstabilität im Vergleich zu unbehandelten bzw. offen gelagerten Proben zu beobachten. Die Ergebnisse werden mit der teilweisen Zerstörung der Isolationseigenschaften des FEP durch eindringende Staubpartikel in Verbindung gebracht.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1982.010330102
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  • 7
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    Abnormal development of kitten retino-geniculate connectivity in the absence of action potentials (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Action potentials were silenced in one eye of neonatal kittens by repeated intraocular injections of tetrodotoxin for 5 to 8 weeks. After tetrodotoxin blockade was allowed to wear off, receptive field properties of individual relay cells in the lateral geniculate nucleus were examined. The many ON-OFF and binocular fields found in the layers that receive input from the treated eye suggest that these cells had extremely abnormal retino-geniculate synaptic connections. These effects were different in kind from those seen after deprivation rearing that does not silence action potentials. Lack of action potential activity was concluded to lead to abnormal development in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Archer, S M -- Dubin, M W -- Stark, L A -- 7F32 EY 05442/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):743-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100921" target="_blank"〉PubMed〈/a〉
    Keywords: *Action Potentials ; Animals ; Animals, Newborn ; Cats/*growth & development ; Evoked Potentials, Visual ; Facial Nerve/*growth & development ; Geniculate Ganglion/*growth & development ; Optic Nerve/growth & development ; Retina/*growth & development ; Sensory Deprivation ; Synapses/physiology ; Tetrodotoxin/pharmacology ; Visual Pathways/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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