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  • Nematode resistance  (6)
  • combinatorial chemistry  (5)
  • Springer  (11)
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  • 1
    Digitale Medien
    Digitale Medien
    Solid phase synthesis of allylic alcohols via the Baylis-Hillman reaction (1997)
    Springer
    Molecular diversity 3 (1997), S. 191-194 
    Details
    ISSN: 1573-501X
    Schlagwort(e): Baylis-Hillman reaction ; combinatorial chemistry ; solid-phase synthesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract An efficient method for the solid phase synthesis of allylic alcohols via the Baylis-Hillman reaction has been developed. In the presence of DABCO® or 3-quinuclidinol the coupling of resin bound acrylic acid with different aldehydes yields allylic alcohols. Aldehydes with different reactivity were used and gave modest to excellent yields upon simply varying the base or the reaction time. The allylic alcohols were reacted with primary amines to form 1,3-aminoalcohols.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1009689804217
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  • 2
    Digitale Medien
    Digitale Medien
    Synthesis of hydantoins via N, N′-ureas derived from polymer-bound amino acids (1997)
    Springer
    Molecular diversity 3 (1997), S. 257-260 
    Details
    ISSN: 1573-501X
    Schlagwort(e): automated synthesis ; combinatorial chemistry ; hydantoins ; imidazolidinediones ; solid phase synthesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Starting from carboxy-linked amino acids on trityl functionalized polystyrene resin a highly efficient solid-phase synthesis of hydantoins via N, N′-ureas was elaborated. The polymer-bound hydantoins can be used as scaffolds for further combinatorial transformations, such as alkylation. Cleavage from the resins yielded the corresponding hydantoins in good yields and purities as shown by ESI-MS and HPLC.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1009639804397
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  • 3
    Digitale Medien
    Digitale Medien
    Composition and Purity of Combinatorial Aryl Ether Collections Analyzed by Electrospray Mass Spectrometry (1997)
    Springer
    Molecular diversity 3 (1997), S. 29-41 
    Details
    ISSN: 1573-501X
    Schlagwort(e): aryl ether library ; combinatorial chemistry ; electrospray mass spectrometry ; HPLC-MS ; molecule libraries ; tandem MS
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Electrospray mass spectrometry (ESI-MS), tandem massspectrometry and on-line RP-HPLC-ESI-MS were used toevaluate the composition and purity of three differentaryl ether mixtures consisting of 10 and 45 arylethers synthesized on solid support by Williamsonetherification. The libraries feature two potentialpharmacophores connected with three different spacersand serve as models for a detailed component analysis.Individual members of the library and by-products wereidentified rapidly and conveniently by product ionscans. Compound collections obtained by two differentsynthetic methods, the split/combine approach and thepremix method, showed different mass distributions inthe ESI-MS spectra. Some components were not detectedin direct ESI-MS measurements, but were found by MS/MSexperiments. Precursor ion and constant neutral lossscans allowed the identification of components withcommon structural features.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1009600806679
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  • 4
    Digitale Medien
    Digitale Medien
    Analysis of DNA from a Beta procumbens chromosome fragment in sugar beet carrying a gene for nematode resistance (1990)
    Springer
    Theoretical and applied genetics 79 (1990), S. 663-672 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Sugar beet ; B. procumbens ; Nematode resistance ; Pulsed-field gel electrophoresis ; DNA probes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary We have begun to apply techniques for the preparation and anaylsis of large DNA segments from sugar beet (Beta vulgaris) addition lines carrying a mitotically stable chromosome fragment from B. procumbens that confers monogenic resistance to the nematode Heterodera schachtii, with a view towards isolating the resistance gene. DNA probes specific for this chromosome fragment were selected, and various methods for cloning genome-specific fragments, including probes from megabase DNA separated in pulsed-field slab gels, are compared. Probes that display high homology to B. procumbens have been used for hybridization of a representative genomic library and for initial step in mapping the chromosome fragment via pulsed-field gel electrophoresis after restriction with infrequently cutting enzymes. Our data indicate that DNA molecules from the entire chomosome fragment can be separated from protoplast DNA lysates.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00226881
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  • 5
    Digitale Medien
    Digitale Medien
    Genetic localization of four genes for nematode (Heterodera schachtii Schm.) resistance in sugar beet (Beta vulgaris L.) (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 991-997 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Key words Sugar beet ; Beta vulgaris ; Nematode resistance ; RFLP ; Genetic maps ; Bulk segregant analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract  Sugar beet (Beta vulgaris L.) is highly susceptible to the beet cyst nematode (Heterodera schachtii Schm.). Three resistance genes originating from the wild beets B. procumbens and B. webbiana have been transferred to sugar beet via species hybridization. We describe the genetic localization of the nematode resistance genes in four different sugar beet lines using segregating populations and RFLP markers from our current sugar beet linkage map. The mapping studies yielded a surprising result. Although the four parental lines carrying the wild beet translocations were not related to each other, the four genes mapped to the same locus in sugar beet independent of the original translocation event. Close linkage (0–4.6 cM) was found with marker loci at one end of linkage group IV. In two populations, RFLP loci showed segregation distortion due to gametic selection. For the first time, the non-randomness of the translocation process promoting gene transfer from the wild beet to the sugar beet is demonstrated. The data suggest that the resistance genes were incorporated into the sugar beet chromosomes by non-allelic homologous recombination. The finding that the different resistance genes are allelic will have major implications on future attempts to breed sugar beet combining the different resistance genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001220050220
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  • 6
    Digitale Medien
    Digitale Medien
    Genetic localization of four genes for nematode (Heterodera schachtii Schm.) resistance in sugar beet (Beta vulgaris L.) (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 991-997 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Sugar beet ; Beta vulgaris ; Nematode resistance ; RFLP ; Genetic maps ; Bulk segregant analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Sugar beet (Beta vulgaris L.) is highly susceptible to the beet cyst nematode (Heterodera schachtii Schm.). Three resistance genes originating from the wild beets B. procumbens (Hs1 pro-1) and B. webbiana (Hs1 web-1, Hs2 web-7) have been transferred to sugar beet via species hybridization. We describe the genetic localization of the nematode resistance genes in four different sugar beet lines using segregating F2 populations and RFLP markers from our current sugar beet linkage map. The mapping studies yielded a surprising result. Although the four parental lines carrying the wild beet translocations were not related to each other, the four genes mapped to the same locus in sugar beet independent of the original translocation event. Close linkage (0–4.6 cM) was found with marker loci at one end of linkage group IV. In two populations, RFLP loci showed segregation distortion due to gametic selection. For the first time, the non-randomness of the translocation process promoting gene transfer from the wild beet to the sugar beet is demonstrated. The data suggest that the resistance genes were incorporated into the sugar beet chromosomes by non-allelic homologous recombination. The finding that the different resistance genes are allelic will have major implications on future attempts to breed sugar beet combining the different resistance genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00224039
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  • 7
    Digitale Medien
    Digitale Medien
    Evaluation of nematode-resistant sugar beet (Beta vulgaris L.) lines by molecular analysis (1998)
    Springer
    Theoretical and applied genetics 97 (1998), S. 896-904 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Key words Beta vulgaris ; Nematode resistance ; Genome-specific markers ; Procumbentes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract  Thirty sugar beet (Beta vulgaris) lines conferring complete resistance to the beet cyst nematode (BCN, Heterodera schachtii) originating from interspecific crosses with wild beets of the section Procumbentes (B. procumbens, B. webbiana and B. patellaris) were investigated by morphology and wild beet-specific molecular markers. The beet lines carrying chromosome mutations consisted of monosomic additions (2n=18+1), fragment additions (2n=18+fragment) and translocations (2n=18) from the wild beets. Genome-specific single-copy, satellite and repetitive probes were applied to study the origin, chromosomal assignment and presence of nematode resistance genes. Within the wild beet species at least three different resistance genes located on different chromosomes were distinguished: Hs1 on the homoelogous chromosomes I of each species, Hs2 on the homoelogous chromosomes VII of B. procumbens and B. webbiana and Hs3 on chromosome VIII of B. webbiana. A clear distinction between the three chromosomes was possible by morphological and molecular means. The translocation lines were separated into two different groups: one containing the resistance gene Hs1 from chromosome I and the other carrying a different nematode resistance gene. The molecular data combined with sequence analyses of Hs1 of the three wild beet species revealed a clear distinction between B. procumbens and B. webbiana. The evolutionary and taxonomical relationship of these species supporting the idea of three different species originating from a common ancestor is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001220050970
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  • 8
    Digitale Medien
    Digitale Medien
    Physical mapping and cloning of a translocation in sugar beet (Beta vulgaris L) carrying a gene for nematode (Heterodera schachtii) resistance from B. procumbens (1995)
    Springer
    Theoretical and applied genetics 90 (1995), S. 399-406 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Sugar beet ; Nematode resistance ; Yeast artificial chromosomes (YACs) ; Contig analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Two diploid (2n=18) sugar beet (Beta vulgaris L.) lines which carry monogenic traits for nematode (Heterodera schachtii Schm.) resistance located on translocations from the wild beet species Beta procumbens were investigated. Short interspersed repetitive DNA elements exclusively hybridizing with wild beet DNA were found to be dispersed around the translocations. The banding pattern as revealed by genomic Southern hybridization was highly conserved among translocation lines of different origins indicating that the translocations are not affected by recombination events with sugar beet chromosomes. Physical mapping revealed that the entire translocation is represented by a single Sal I fragment 300 kb in size. A representative YAC (yeast artifical chromosome) library consisting of approximately 13,000 recombinant clones (2.2 genome equivalents) with insert sizes ranging between 50 and 450 kb and an average of 130kb has been constructed from the resistant line A906001. Three recombinant YACs were isolated from this library using the wild beet-specific repetitive elements as probes for screening. Colinearity between YAC inserts and donor DNA was confirmed by DNA fingerprinting utilizing these repetitive probes. The YACs were arranged into two contigs with a total size of 215 kb; these represent a minimum of 72% of the translocation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00221982
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  • 9
    Digitale Medien
    Digitale Medien
    DNA markers closely linked to nematode resistance genes in sugar beet (Beta vulgaris L.) mapped using chromosome additions and translocations originating from wild beets of the Procumbentes section (1992)
    Springer
    Molecular genetics and genomics 232 (1992), S. 271-278 
    Details
    ISSN: 1617-4623
    Schlagwort(e): Beta species ; Sugar beet ; Nematode resistance ; Repetitive sequences ; Polymerase chain reaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Genes conferring resistance to the beet cyst nematode (Heterodera schachtii Schm.) have been transferred to sugar beet (Beta vulgaris L.) from three wild species of the Procumbentes section using monosomic addition and translocation lines, because no meiotic recombination occurs between chromosomes of cultured and wild species. In the course of a project to isolate the nematode resistance genes by strategies of reverse genetics, probes were cloned from DNA of a fragmented B. procumbens chromosome carrying a resistance gene, which had been isolated by pulsed-field gel electrophoresis. One probe (pRK643) hybridized with a short dispersed repetitive DNA element, which was found only in wild beets, and thus may be used as a molecular marker for nematode resistance to progenies of monosomic addition lines segregating resistant and susceptible individuals. Additional probes for the resistance gene region were obtained with a polymerase chain reaction (PCR)-based strategy using repetitive primers to amplify DNA located between repetitive elements. One of these probes established the existence of at least six different chromosomes from wild beet species, each conferring resistance independently of the others. A strict correlation between the length of the wild beet chromatin introduced in fragment addition and translocation lines and the repeat copy number has been used physically to map the region conferring resistance to a chromosome segment of 0.5-3 Mb.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00280006
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  • 10
    Digitale Medien
    Digitale Medien
    Oligocarbamates as MHC class I ligands (1998)
    Springer
    International journal of peptide research and therapeutics 5 (1998), S. 125-128 
    Details
    ISSN: 1573-3904
    Schlagwort(e): combinatorial chemistry ; MHC ; peptidomimetics ; solid-phase synthesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary New ligands for major histocompatibility complex (MHC) class I molecules were prepared using a flexible automated synthesis of oligocarbamates. An efficient solution-phase synthesis was found for Fmoc-amino alcohols which are required as building blocks. The biological activity of the oligomeric peptidomimetics was demonstrated in a stabilizing assay with MHC class I presenting cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02443453
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