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  • Mitochondrial DNA  (2)
  • drug interaction  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Renal clearance of lomefloxacin is decreased by furosemide (1994)
    Springer
    European journal of clinical pharmacology 46 (1994), S. 267-269 
    Details
    ISSN: 1432-1041
    Keywords: Lomefloxacin ; Furosemide ; Renal clearance ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The interaction between lomefloxacin, a new quinolone, and furosemide, a loop diuretic, has been examined. Oral lomefloxacin 200 mg and furosemide 40 mg were given together or separately to 8 healthy subjects, and blood and urine samples were obtained over the following 12 h. The plasma concentrations of lomefloxacin following coadministration with furosemide were higher than after lomefloxacin alone and its AUC was increased, and its total and renal clearances were decreased. No change in the pharmacokinetics of furosemide was found after coadministration of lomefloxacin. As quinolones and furosemide are reported to be excreted in urine by the renal tubular anion transport system, the present results suggest that the renal tubular secretion of lomefloxacin is diminished by furosemide. It is not clear whether this pharmacokinetic interaction might be clinically important.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192560
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of ranitidine on renal clearance of lomefloxacin (1996)
    Springer
    European journal of clinical pharmacology 51 (1996), S. 95-98 
    Details
    ISSN: 1432-1041
    Keywords: Key words Lomefloxacin ; Ranitidine; renal clearance ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To examine the effect of ranitidine on the renal clearance of lomefloxacin. Setting: Department of Clinical Pharmacology, Jichi Medical School. Methods: Lomefloxacin 200 mg and ranitidine 300 mg or its placebo were given orally in a randomised, double-blind, crossover design. Blood and urine samples were obtained during a 24-h period after dosing. Results: The area under the plasma concentration-time curve and the elimination half-life of lomefloxacin were significantly increased following coadministration with ranitidine. These effects were caused by significant decreases in total (7.8%) and renal (22%) clearance of lomefloxacin. In contrast, creatinine clearance and urinary excretion of electrolytes were not influenced by ranitidine. Conclusion: As lomefloxacin and ranitidine are excreted in urine by renal tubular secretion, the present results suggest that the renal tubular secretion of lomefloxacin is diminished by ranitidine. As the reduction in lomefloxacin clearance is only marginal, it is probable that the drug interaction observed in this study is not of clinical significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050167
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  • 3
    Electronic Resource
    Electronic Resource
    Distribution of mitochondrial plasmid-like DNA in cultivated rice (Oryza sativa L.) and its relationship with varietal groups (1988)
    Springer
    Theoretical and applied genetics 76 (1988), S. 809-814 
    Details
    ISSN: 1432-2242
    Keywords: Electron microscopy ; Genetic variation ; Mitochondrial DNA ; Oryza sativa L. ; Plasmid-like DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mitochondrial (mt) plasmid-like DNA was found in most of more than 100 rice cultivars (Oryza sativa L.) by the use of 0.7% agarose gel electrophoresis (AGE). The DNA varied in molecular weight and number. By electron microscopy, small circular DNAs of different sizes could be detected in addition to the DNAs of high molecular weight, even in cultivars in which mt plasmid-like DNA was not detected by AGE. The detection of the mt plasmid-like DNAs by AGE did not depend on their presence or absence, but on their high stoichiometry. The relationship between cytoplasms with mt plasmid-like DNAs and varietal (for example, Indica rice) groups was close. The geographical distribution of cytoplasms is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273665
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  • 4
    Electronic Resource
    Electronic Resource
    Mitochondrial DNA polymorphism in male-sterile cytoplasm of rice (1988)
    Springer
    Theoretical and applied genetics 75 (1988), S. 234-236 
    Details
    ISSN: 1432-2242
    Keywords: Male-sterile cytoplasm ; Mitochondrial DNA ; Restriction fragment length polymorphism ; Rice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mitochondrial DNAs (mtDNAs) were isolated and purified from ten strains of rice plants with male-sterile cytoplasm. The mtDNAs were digested with the restriction endonuclease PstI and the fragment patterns produced were analysed by 0.7% agarose gel electrophoresis. Restriction fragment length polymorphism was observed among the mtDNAs analysed; there were seven different patterns for the ten examined. Our results indicate that there are a variety of mtDNAs in cytoplasmically male-sterile rice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303958
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