Abstract
The interaction between lomefloxacin, a new quinolone, and furosemide, a loop diuretic, has been examined. Oral lomefloxacin 200 mg and furosemide 40 mg were given together or separately to 8 healthy subjects, and blood and urine samples were obtained over the following 12 h.
The plasma concentrations of lomefloxacin following coadministration with furosemide were higher than after lomefloxacin alone and its AUC was increased, and its total and renal clearances were decreased. No change in the pharmacokinetics of furosemide was found after coadministration of lomefloxacin.
As quinolones and furosemide are reported to be excreted in urine by the renal tubular anion transport system, the present results suggest that the renal tubular secretion of lomefloxacin is diminished by furosemide. It is not clear whether this pharmacokinetic interaction might be clinically important.
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References
Wolfson JS, Hooper DC (1989) Fluoroquinolone antimicrobial agents. Clin Microbiol Rev 2: 378–424
Nakashima M, Uematsu T, Takiguchi Y, Mizuno A, Kanamaru M, Kubo S, Takahara Y, Okezaki E, Nagata O (1988) Phase I study on NY-198. Chemotherapy (Tokyo) 36 [Suppl 2]: 201–239
Fitton A (1992) The quinolones: an overview of their pharmacology. Clin Pharmacokinet 22 [Suppl 1]: 1–11
Van Ginneken CAM, Russel FGM (1989) Saturable pharmacokinetics in the renal excretion of drugs. Clin Pharmacokinet 16: 38–54
Okezaki E, Makino E, Ohmichi K, Nagata O, Yamada T, Takahashi K, Terasaki T, Tsuji A (1988) Disposition and metabolism of NY-198; II HPLC and bioassay studies of absorption and excretion in the dog. Chemotherapy (Tokyo) 36 [Suppl 2]: 139–143
MacDougall ML, Shoeman DW, Azarnoff DL (1975) Separation and quantitative analysis of furosemide and 4-chloro-5-sulfamoyl-anthranilic acid (CSA) by high pressure liquid chromatography. Res Commun Chem Pathol Pharmacol 10: 285–292
Stein JH, Wilson CB, Kirkendall WM (1968) Differences in the acute effects of furosemide and ethacrynic acid in man. J Lab Clin Med 71: 654–665
Puschett JB, Goldberg M (1968) The acute effects of furosemide on acid and electrolyte excretion in man. J Lab Clin Med 71: 666–677
Odlind B, Beermann B (1980) Renal tubular secretion and effects of furosemide. Clin Pharmacol Ther 27: 784–790
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Sudoh, T., Fujimura, A., Shiga, T. et al. Renal clearance of lomefloxacin is decreased by furosemide. Eur J Clin Pharmacol 46, 267–269 (1994). https://doi.org/10.1007/BF00192560
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DOI: https://doi.org/10.1007/BF00192560