Publication Date:
2013-01-19
Description:
Environmental stressors during childhood and adolescence influence postnatal brain maturation and human behavioral patterns in adulthood. Accordingly, excess stressors result in adult-onset neuropsychiatric disorders. We describe an underlying mechanism in which glucocorticoids link adolescent stressors to epigenetic controls in neurons. In a mouse model of this phenomenon, a mild isolation stress affects the mesocortical projection of dopaminergic neurons in which DNA hypermethylation of the tyrosine hydroxylase gene is elicited, but only when combined with a relevant genetic risk for neuropsychiatric disorders. These molecular changes are associated with several neurochemical and behavioral deficits that occur in this mouse model, all of which are blocked by a glucocorticoid receptor antagonist. The biology and phenotypes of the mouse models resemble those of psychotic depression, a common and debilitating psychiatric disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617477/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617477/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niwa, Minae -- Jaaro-Peled, Hanna -- Tankou, Stephanie -- Seshadri, Saurav -- Hikida, Takatoshi -- Matsumoto, Yurie -- Cascella, Nicola G -- Kano, Shin-ichi -- Ozaki, Norio -- Nabeshima, Toshitaka -- Sawa, Akira -- K99 MH094408/MH/NIMH NIH HHS/ -- K99MH-094408/MH/NIMH NIH HHS/ -- MH-069853/MH/NIMH NIH HHS/ -- MH-084018/MH/NIMH NIH HHS/ -- MH-085226/MH/NIMH NIH HHS/ -- MH-088753/MH/NIMH NIH HHS/ -- MH-092443/MH/NIMH NIH HHS/ -- MH-094268/MH/NIMH NIH HHS/ -- R01 MH092443/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 18;339(6117):335-9. doi: 10.1126/science.1226931.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Pharmacology, Meijo University Graduate School of Pharmaceutical Sciences, Nagoya, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23329051" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
*Adolescent Behavior
;
*Adolescent Development
;
Affective Disorders, Psychotic/genetics/*metabolism
;
Animals
;
Disease Models, Animal
;
Dopaminergic Neurons/*metabolism
;
*Epigenesis, Genetic
;
Glucocorticoids/*metabolism
;
Humans
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Nerve Tissue Proteins/genetics/metabolism
;
Stress, Psychological/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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