Publication Date:
1981-06-19
Description:
The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barrett, J C -- Wong, A -- McLachlan, J A -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1402-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262919" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Benzo(a)pyrene
;
Benzopyrenes
;
Carcinogens
;
*Cell Transformation, Neoplastic
;
Cells, Cultured
;
Cricetinae
;
Diethylstilbestrol/*pharmacology
;
Embryo, Mammalian
;
Genes/*drug effects
;
Mesocricetus
;
*Mutation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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