Publication Date:
1997-11-21
Description:
The Janus family of tyrosine kinases (JAK) plays an essential role in development and in coupling cytokine receptors to downstream intracellular signaling events. A t(9;12)(p24;p13) chromosomal translocation in a T cell childhood acute lymphoblastic leukemia patient was characterized and shown to fuse the 3' portion of JAK2 to the 5' region of TEL, a gene encoding a member of the ETS transcription factor family. The TEL-JAK2 fusion protein includes the catalytic domain of JAK2 and the TEL-specific oligomerization domain. TEL-induced oligomerization of TEL-JAK2 resulted in the constitutive activation of its tyrosine kinase activity and conferred cytokine-independent proliferation to the interleukin-3-dependent Ba/F3 hematopoietic cell line.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lacronique, V -- Boureux, A -- Valle, V D -- Poirel, H -- Quang, C T -- Mauchauffe, M -- Berthou, C -- Lessard, M -- Berger, R -- Ghysdael, J -- Bernard, O A -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1309-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉U 301 de l'Institut National de la Sante et de la Recherche Medicale and SD 401 No. 301 CNRS, Institut de Genetique Moleculaire, 27 rue Juliette Dodu, 75010 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9360930" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Biopolymers
;
Cell Division
;
Cell Line
;
Child, Preschool
;
DNA-Binding Proteins/chemistry/genetics/metabolism
;
Enzyme Activation
;
Humans
;
Interleukin-3/physiology
;
Janus Kinase 2
;
Leukemia-Lymphoma, Adult T-Cell/genetics/*metabolism
;
Male
;
Mice
;
*Milk Proteins
;
Molecular Sequence Data
;
Oncogene Proteins, Fusion/chemistry/genetics/*metabolism
;
Phosphorylation
;
Protein-Tyrosine Kinases/chemistry/genetics/*metabolism
;
*Proto-Oncogene Proteins
;
Proto-Oncogene Proteins c-ets
;
*Repressor Proteins
;
STAT5 Transcription Factor
;
Signal Transduction
;
Trans-Activators/metabolism
;
Transcription Factors/chemistry/genetics/metabolism
;
Transfection
;
Translocation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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