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  • 1
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    A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2 (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-10
    Description: The stimulation of phospholipase A2 by thrombin and type 2 (P2)-purinergic receptor agonists in Chinese hamster ovary cells is mediated by the G protein Gi. To delineate alpha chain regulatory regions responsible for control of phospholipase A2, chimeric cDNAs were constructed in which different lengths of the alpha subunit of Gs (alpha s) were replaced with the corresponding sequence of the Gi alpha subunit (alpha i2). When a carboxyl-terminal chimera alpha s-i(38), which has the last 38 amino acids of alpha s substituted with the last 36 residues of alpha i2, was expressed in Chinese hamster ovary cells, the receptor-stimulated phospholipase A2 activity was inhibited, although the chimera could still activate adenylyl cyclase. Thus, alpha s-i(38) is an active alpha s, but also a dominant negative alpha i molecule, indicating that the last 36 amino acids of alpha i2 are a critical domain for G protein regulation of phospholipase A2 activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, S K -- Diez, E -- Heasley, L E -- Osawa, S -- Johnson, G L -- DK37871/DK/NIDDK NIH HHS/ -- GM30324/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Aug 10;249(4969):662-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2166341" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/pharmacology ; Animals ; Arachidonic Acid ; Arachidonic Acids/metabolism ; Cell Line ; Chlorides/pharmacology ; Enzyme Activation ; GTP-Binding Proteins/*genetics/metabolism ; Inositol Phosphates/metabolism ; Kinetics ; Lithium/pharmacology ; Lithium Chloride ; Macromolecular Substances ; *Mutation ; Phospholipases/*metabolism ; Phospholipases A/*metabolism ; Phospholipases A2 ; Receptors, Purinergic/drug effects/*physiology ; Restriction Mapping ; Thrombin/antagonists & inhibitors/*pharmacology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Computer program for solution of large, sparse, unsymmetric systems of linear equations (1977)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 11 (1977), S. 1251-1259 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A computer program is presented for in-core solution of a large, sparse, unsymmetric, unbanded system of linear equations. The program employs two partially packed arrays (one for storing non-zero elements, and one for column identifications). Used as the pivotal row is the row with the minimum number of non-zero elements. To avoid instability, the pivot is the largest absolute element in the pivotal row. The method was tested on a system of equations encountered in field application of the three-dimensional Galerkin finite element solution of flow and mass transport through porous media. Performance is compared with that of available alternatives.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620110806
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  • 3
    Electronic Resource
    Electronic Resource
    Letters to the editor (1978)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 12 (1978), S. 1772-1773 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620121114
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  • 4
    Electronic Resource
    Electronic Resource
    On some Oxozirconium(IV) Compounds (1976)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 423 (1976), S. 91-96 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Über einige Zirkonium (IV)-oxid-VerbindungenEinige neue Zirlconium(IV)-oxid-Komplexe, ZrO(An)2, ZrO(Gly)2, ZrO(HSal)2, ZrO(HPth)2, ZrO(Pic)2(HPic)2 und ZrO(Quin)2(HQuin)2 wurden dargestellt durch Reaktion von ZrO(CH3C00)2CH3COOH mit Anthranilsäure (HAn), Glycin (HGly), Salicylsäure (H2Sal), Phthalsäure (H2Pth), Picolinsänre (HPic) und 8-Oxychinolin (HQuin). Ihre wichtigsten IR-Banden und, soweit möglich, molaren Leitfähigkeiten und Molekulargewichte werden mitgeteilt.
    Notes: Some new oxozirconium(IV) complexes: ZrO(An)2, ZrO(Gly)2, ZrO(HSal)2, ZrO(HPth)2, ZrO(Pic)2(HPic)2, and ZrO(Quin)2(H Quin)2 have been isolated from the reactions of ZrO(CH3COO)2CH3COOH with anthranilic acid (HAn), glycine (HGly), salicylic acid (H2Sal), phthalic acid (H2Pth), picolinic acid (HPic), and 8-quinolinol (HQuin) respectively. Their important infrared bands and wherever possible molar conductance and molecular weight have been reported.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19764230113
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  • 5
    Electronic Resource
    Electronic Resource
    Chemistry of Substituted Sulphuric Acids. X. Acids and Bases in Methanesulphuric Acid Solvent System (1980)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 471 (1980), S. 203-207 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Chemie substituierter Schwefelsäuren. X. Lösungen von Säuren und Basen in MethansulfonsäurenMethansulfonsäure ist schwächer als Schwefelsäure. Eine Zahl von anorganischen protonischen Säuren wirken in Methansulfonsäure gelöst als Säuren, während starke Basen vollständig protoniert werden. Säure-Base-Titrationen in Methansulfonsäure zeigen bei starken Säuren, daß die elektrische Leitung über CH3SO3H2+ - und CH3SO3- - Ionen erfolgt. Leitfähigkeitsmessungen zeigen die Reihenfolge der Säurestärken, s. Abstract.
    Notes: Methanesulphuric acid is weaker than sulphuric acid. A number of inorganic protonic acids act as acids in it while the strong bases are fully protonated. The acid-base titrations in it with strong acids indicate that the bulk of the current is carried by CH3SO3H2+ and CH3SO3- ions. The conductance measurements indicate that the order of the acid strength is: H[B(HSO4)4] 〉 HSO3F 〉 H2S2O7 〉 HAs(HSO4)4 〉 HSO3Cl 〉 H2SO4 〉 HX (X=Br 〉 Cl) 〉 H2SeO4.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19804710123
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