Publication Date:
1993-06-04
Description:
Activity-dependent synaptic plasticity in the superficial layers of juvenile cat and adult rat visual neocortex was compared with that in adult rat hippocampal field CA1. Stimulation of neocortical layer IV reliably induced synaptic long-term potentiation (LTP) and long-term depression (LTD) in layer III with precisely the same types of stimulation protocols that were effective in CA1. Neocortical LTP and LTD were specific to the conditioned pathway and, as in the hippocampus, were dependent on activation of N-methyl-D-aspartate receptors. These results provide strong support for the view that common principles may govern experience-dependent synaptic plasticity in CA1 and throughout the superficial layers of the mammalian neocortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirkwood, A -- Dudek, S M -- Gold, J T -- Aizenman, C D -- Bear, M F -- New York, N.Y. -- Science. 1993 Jun 4;260(5113):1518-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Brown University, Providence, RI 02912.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8502997" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Aging/physiology
;
Animals
;
Cats
;
Cerebral Cortex/*physiology
;
Electric Stimulation
;
Hippocampus/*physiology
;
In Vitro Techniques
;
Neural Pathways/physiology
;
Neuronal Plasticity/*physiology
;
Rats
;
Receptors, N-Methyl-D-Aspartate/physiology
;
Synapses/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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