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  • 1
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    Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-06-05
    Description: The bcl-2 and c-myc proto-oncogenes are brought into juxtaposition with the immunoglobulin heavy chain locus in particular B-cell lymphomas, resulting in high levels of constitutive accumulation of their messenger RNAs. Precisely how the products of the bcl-2 and c-myc genes contribute to tumorigenesis is unknown, but observations that c-myc expression is rapidly induced in nonneoplastic lymphocytes upon stimulation of proliferation raise the possibility that this proto-oncogene is involved in the control of normal cellular growth. In addition to c-myc, the bcl-2 proto-oncogene also was expressed in normal human B and T lymphocytes after stimulation with appropriate mitogens. Comparison of the regulation of the expression of these proto-oncogenes demonstrated marked differences and provided evidence that, in contrast to c-myc, levels of bcl-2 messenger RNA are regulated primarily through transcriptional mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reed, J C -- Tsujimoto, Y -- Alpers, J D -- Croce, C M -- Nowell, P C -- CA-42232/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Jun 5;236(4806):1295-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3495884" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Proteins/biosynthesis/drug effects ; Cycloheximide/pharmacology ; Gene Expression Regulation/*drug effects ; Humans ; Interleukin-2/pharmacology ; Kinetics ; Lymphocyte Activation/*drug effects ; Phytohemagglutinins/pharmacology ; Proto-Oncogenes/*drug effects ; RNA, Messenger/blood/drug effects ; Transcription, Genetic/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Deregulation of c-myc by translocation of the alpha-locus of the T-cell receptor in T-cell leukemias (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-16
    Description: Two human T-cell leukemias carrying a t(8;14)(q24;q11) chromosome translocation were studied for rearrangements and expression of the c-myc oncogene. For one leukemia, rearrangement was detected in a region immediately distal (3') to the c-myc locus; no rearrangements of c-myc were observed in the second case (DeF). However, studies with hybrids between human and mouse leukemic T cells indicated that in the leukemic cells of DeF, the breakpoint in chromosome 14 occurred between genes for the variable (V alpha) and the constant (C alpha) regions for the alpha chain of the T-cell receptor. The C alpha locus had translocated to a region more than 38 kilobases 3' to the involved c-myc oncogene. Since human c-myc transcripts were expressed only in hybrids carrying the 8q+ chromosome but not in hybrids containing the normal chromosome 8, it is concluded that the translocation of the C alpha locus 3' to the c-myc oncogene can result in its transcriptional deregulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erikson, J -- Finger, L -- Sun, L -- ar-Rushdi, A -- Nishikura, K -- Minowada, J -- Finan, J -- Emanuel, B S -- Nowell, P C -- Croce, C M -- CA10815/CA/NCI NIH HHS/ -- CA25875/CA/NCI NIH HHS/ -- CA39860/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1986 May 16;232(4752):884-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3486470" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Burkitt Lymphoma/genetics ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 6-12 and X ; Humans ; Hybrid Cells ; Karyotyping ; Leukemia/*genetics ; Male ; Mice ; Middle Aged ; Nucleic Acid Hybridization ; *Oncogenes ; Receptors, Antigen, T-Cell/*genetics ; *T-Lymphocytes ; *Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: Mouse lymphoma cells were hybridized with two human acute T-cell leukemias with a t(11;14) (p13;q11) translocation and the segregated hybrids were examined for the presence of the DNA segments coding for the constant (C) and the variable (V) regions of the alpha chain (C alpha and V alpha) of the T-cell receptor. The C alpha segment was translocated to the involved chromosome 11 (11p+) while the V alpha segment remained on the involved chromosome 14 (14q-). The data indicate that the locus for the alpha chain of the T-cell receptor is split by the chromosomal breakpoint between the V alpha and the C alpha gene segments, and that the V alpha segments are proximal to the C alpha segment within chromosome band 14q11.2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erikson, J -- Williams, D L -- Finan, J -- Nowell, P C -- Croce, C M -- CA16685/CA/NCI NIH HHS/ -- CA36521/CA/NCI NIH HHS/ -- CA39860/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):784-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3875152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Chromosomes, Human, 13-15 ; *Chromosomes, Human, 6-12 and X ; Gene Expression Regulation ; Genes ; Humans ; Leukemia/*genetics ; Oncogenes ; Receptors, Antigen, T-Cell/*genetics ; T-Lymphocytes/physiology ; *Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-03
    Description: The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Isobe, M -- Erikson, J -- Emanuel, B S -- Nowell, P C -- Croce, C M -- CA15822/CA/NCI NIH HHS/ -- CA16685/CA/NCI NIH HHS/ -- GM20700/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 May 3;228(4699):580-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3983641" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Ataxia Telangiectasia/genetics ; Chromosome Aberrations/genetics ; Chromosome Disorders ; *Chromosome Mapping ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 6-12 and X ; Female ; Humans ; Male ; Mice ; Receptors, Antigen, T-Cell/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-29
    Description: The chromosomal breakpoint of chronic lymphocytic leukemia (CLL) cells of the B-cell type carrying the translocated long arms of chromosomes 11 and 14 [t(11;14) (q13;q32)] was cloned. The breakpoint was found to be within the joining segment of the human heavy chain locus on the translocated long arm of chromosome 14. A probe that is specific for chromosome 11 and that maps immediately 5' to the breakpoint on the 14q+ chromosome was isolated. The probe detected a rearrangement of the homologous genomic DNA segment in the parental CLL cells and also in DNA from a diffuse large cell lymphoma with the t(11;14) translocation. This rearranged DNA segment was not present in Burkitt lymphoma cells with the t(8;14) translocation or in nonneoplastic human lymphoblastoid cells. The probe can thus be used to identify and characterize a gene located on band q13 of chromosome 11 that appears to be involved in the malignant transformation of human B cells carrying the t(11;14) translocation. This gene, named bcl -1, appears to be unrelated to any of the known retrovirus oncogenes described to date.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsujimoto, Y -- Yunis, J -- Onorato-Showe, L -- Erikson, J -- Nowell, P C -- Croce, C M -- CA15882/CA/NCI NIH HHS/ -- CA16685/CA/NCI NIH HHS/ -- CA20034/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1403-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6610211" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Animals ; B-Lymphocytes ; Burkitt Lymphoma/genetics ; Cell Line ; *Chromosomes, Human, 13-15 ; *Cloning, Molecular ; DNA, Neoplasm/genetics ; DNA, Recombinant/metabolism ; Humans ; Hybrid Cells/metabolism ; Leukemia/*genetics ; Leukemia, Lymphoid/genetics ; Lymphoma/*genetics ; Male ; Mice ; Nucleic Acid Hybridization ; *Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-30
    Description: From an acute B-cell leukemia cell line, a DNA probe was obtained that was specific for chromosome 18 and flanked the heavy chain joining region of the immunoglobulin heavy chain locus on chromosome 14. This probe detected rearrangement of the homologous DNA segment in the leukemic cells and in follicular lymphoma cells with the t(14:18) chromosome translocation but not in other neoplastic or normal B or T cells. The probe appears to identify bcl-2, a gene locus on chromosome 18 (band q21) that is unrelated to known oncogenes and may be important in the pathogenesis of B-cell neoplasms with this translocation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsujimoto, Y -- Finger, L R -- Yunis, J -- Nowell, P C -- Croce, C M -- CA15822/CA/NCI NIH HHS/ -- CA16685/CA/NCI NIH HHS/ -- CA20034/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Nov 30;226(4678):1097-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6093263" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/*cytology ; Chromosome Banding ; *Chromosomes, Human, 13-15 ; *Chromosomes, Human, 16-18 ; *Cloning, Molecular ; Cricetinae ; Cricetulus ; DNA Restriction Enzymes ; DNA, Recombinant/analysis ; Humans ; Hybrid Cells/cytology ; Karyotyping ; Leukemia/*genetics ; Mice ; *Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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