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  • 1
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    Food production, population growth, and the environment (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-09-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daily, G -- Dasgupta, P -- Bolin, B -- Crosson, P -- du Guerny, J -- Ehrlich, P -- Folke, C -- Jansson, A M -- Jansson, B -- Kautsky, N -- Kinzig, A -- Levin, S -- Maler, K G -- Pinstrup-Andersen, P -- Siniscalco, D -- Walker, B -- New York, N.Y. -- Science. 1998 Aug 28;281(5381):1291-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Stanford University, Stanford, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9735046" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agriculture ; Developed Countries ; Developing Countries ; Environment ; *Food Supply ; Humans ; *Population Growth ; *Public Policy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-12-31
    Beschreibung: Virus-specific CD4+ T helper lymphocytes are critical to the maintenance of effective immunity in a number of chronic viral infections, but are characteristically undetectable in chronic human immunodeficiency virus-type 1 (HIV-1) infection. In individuals who control viremia in the absence of antiviral therapy, polyclonal, persistent, and vigorous HIV-1-specific CD4+ T cell proliferative responses were present, resulting in the elaboration of interferon-gamma and antiviral beta chemokines. In persons with chronic infection, HIV-1-specific proliferative responses to p24 were inversely related to viral load. Strong HIV-1-specific proliferative responses were also detected following treatment of acutely infected persons with potent antiviral therapy. The HIV-1-specific helper cells are likely to be important in immunotherapeutic interventions and vaccine development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, E S -- Billingsley, J M -- Caliendo, A M -- Boswell, S L -- Sax, P E -- Kalams, S A -- Walker, B D -- F32-AI09738/AI/NIAID NIH HHS/ -- R01-A136550/PHS HHS/ -- R01-AI28568/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Nov 21;278(5342):1447-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9367954" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Anti-HIV Agents/therapeutic use ; Chemokines/biosynthesis ; Cohort Studies ; Cytotoxicity, Immunologic ; Disease Progression ; Drug Therapy, Combination ; HIV Core Protein p24/immunology ; HIV Envelope Protein gp160/immunology ; HIV Infections/drug therapy/*immunology/*virology ; HIV-1/*immunology/physiology ; Humans ; Immunologic Memory ; Interferon-gamma/biosynthesis ; Lymphocyte Activation ; Molecular Sequence Data ; Peptide Fragments/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Helper-Inducer/*immunology ; Viral Load ; Viremia/*immunology/virology ; Virus Replication
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-08-15
    Beschreibung: Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen-dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anzick, S L -- Kononen, J -- Walker, R L -- Azorsa, D O -- Tanner, M M -- Guan, X Y -- Sauter, G -- Kallioniemi, O P -- Trent, J M -- Meltzer, P S -- New York, N.Y. -- Science. 1997 Aug 15;277(5328):965-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cancer Genetics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9252329" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Breast/metabolism ; Breast Neoplasms/*genetics/metabolism ; Chromosomes, Human, Pair 20 ; Cloning, Molecular ; Estradiol/metabolism/pharmacology ; Female ; *Gene Amplification ; Gene Dosage ; Gene Expression Regulation, Neoplastic ; Histone Acetyltransferases ; Humans ; In Situ Hybridization, Fluorescence ; Ligands ; Molecular Sequence Data ; Neoplasms, Hormone-Dependent/*genetics/metabolism ; Nuclear Receptor Coactivator 1 ; Nuclear Receptor Coactivator 2 ; Ovarian Neoplasms/*genetics/metabolism ; Receptors, Estrogen/genetics/*metabolism ; Transcription Factors/genetics ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Mental health and disability (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-12-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, R D -- Howard, M O -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1593-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8984617" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cost of Illness ; Depressive Disorder/epidemiology ; Developed Countries ; Developing Countries ; *Disabled Persons ; Humans ; Mental Disorders/*epidemiology ; United States/epidemiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-11-22
    Beschreibung: Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J R -- Freije, D -- Carpten, J D -- Gronberg, H -- Xu, J -- Isaacs, S D -- Brownstein, M J -- Bova, G S -- Guo, H -- Bujnovszky, P -- Nusskern, D R -- Damber, J E -- Bergh, A -- Emanuelsson, M -- Kallioniemi, O P -- Walker-Daniels, J -- Bailey-Wilson, J E -- Beaty, T H -- Meyers, D A -- Walsh, P C -- Collins, F S -- Trent, J M -- Isaacs, W B -- CA58236/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Nov 22;274(5291):1371-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Center for Human Genome Research, National Institutes of Health, Bethesda, MD, USA. jtrent@nchgr.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8910276" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Aged, 80 and over ; *Chromosome Mapping ; *Chromosomes, Human, Pair 1 ; Dinucleotide Repeats ; *Genes ; Genetic Linkage ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Likelihood Functions ; Male ; Middle Aged ; North America ; Oncogenes ; Pedigree ; Prostatic Neoplasms/*genetics ; Risk Factors ; Statistics, Nonparametric ; Sweden
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Modulation of spasticity: prolonged suppression of a spinal reflex by electrical stimulation (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1982-04-09
    Beschreibung: Electrical subcutaneous nerve stimulation of radial, median, and saphenous nerves has been shown to produce prolonged analgesia. In a double blind study, such stimulation also suppressed clonus for 3 hours after stimulation ceased in subjects with spasticity. Since the effect is contralateral, each subject was his own control. Because stimulation of the nerve in the wrist suppressed ankle clonus, the mechanism mediating the effect must be centrifugal inhibition. These results suggest that subcutaneous nerve stimulation may also be a tool in the management of spasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, J B -- New York, N.Y. -- Science. 1982 Apr 9;216(4542):203-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063882" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Electric Stimulation ; Functional Laterality ; Humans ; Motor Neurons/physiopathology ; Muscle Spasticity/physiopathology/*therapy ; Peripheral Nerves/physiopathology ; Reflex/physiology ; Spinal Cord/physiopathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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