Publication Date:
2002-10-26
Description:
The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lunyak, Victoria V -- Burgess, Robert -- Prefontaine, Gratien G -- Nelson, Charles -- Sze, Sing-Hoi -- Chenoweth, Josh -- Schwartz, Phillip -- Pevzner, Pavel A -- Glass, Christopher -- Mandel, Gail -- Rosenfeld, Michael G -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1747-52. Epub 2002 Oct 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute (HHMI), Department of Computer Science and Engineering, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093-0648, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399542" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Binding Sites
;
Carrier Proteins
;
Cell Line
;
*Chromosomal Proteins, Non-Histone
;
Chromosomes/*genetics/metabolism
;
Chromosomes, Human/genetics/metabolism
;
Co-Repressor Proteins
;
Computational Biology
;
CpG Islands
;
DNA Methylation
;
DNA-Binding Proteins/metabolism
;
Gene Expression Profiling
;
Gene Expression Regulation
;
*Gene Silencing
;
Histone Deacetylases/metabolism
;
Humans
;
Intracellular Signaling Peptides and Proteins
;
Membrane Proteins
;
Methyl-CpG-Binding Protein 2
;
Mice
;
Models, Genetic
;
NAV1.2 Voltage-Gated Sodium Channel
;
Nerve Growth Factors/genetics
;
Nerve Tissue Proteins/chemistry/genetics/*metabolism
;
Neurons/*metabolism
;
Promoter Regions, Genetic
;
Protein Structure, Tertiary
;
Rats
;
Repressor Proteins/chemistry/*metabolism
;
Sodium Channels/genetics
;
Transcription Factors/chemistry/*metabolism
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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