Publication Date:
1993-12-10
Description:
Transmission of an external signal from receptors to downstream targets is often mediated by a conserved set of protein kinases that act in sequence (a kinase cascade). In haploid strains of Saccharomyces cerevisiae, a signal initiated by peptide pheromones is transmitted through this kinase cascade to a transcription factor STE12, which is required for the expression of many mating-specific genes. Here it was shown that in diploids some of the same kinases and STE12 are required for filamentous growth, but the pheromone receptors and guanosine triphosphate-binding protein are not required for filament formation. Thus, a similar kinase cascade is activated by different signals in haploids and diploids and mediates different developmental outcomes in the two cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, H -- Styles, C A -- Fink, G R -- GM 35010/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 10;262(5140):1741-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8259520" target="_blank"〉PubMed〈/a〉
Keywords:
Fungal Proteins/*metabolism
;
GTP-Binding Proteins/metabolism
;
Genes, Fungal
;
Mutation
;
Peptides/*metabolism/pharmacology
;
Phenotype
;
Protein Kinases/*metabolism
;
Receptors, Mating Factor
;
Receptors, Peptide/metabolism
;
Saccharomyces cerevisiae/genetics/*growth & development/metabolism
;
*Saccharomyces cerevisiae Proteins
;
*Signal Transduction
;
Transcription Factors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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