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  • 1
    Electronic Resource
    Electronic Resource
    Cloning and characterization of an apoptosis-associated gene in the human placenta (2000)
    Springer
    Apoptosis 5 (2000), S. 53-60 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; differential display ; human ; placenta.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Placenta is a transient feto-maternal association that develops during mammalian pregnancies. Human placental tissue during the first trimester of pregnancy is an actively dividing and differentiating tissue, while near term, it represents a fully differentiated unit performing many life-sustaining functions for the fetus. Previous studies have demonstrated that the percentage of placental cells that undergo apoptosis is greater at full term as compared to the first trimester of pregnancy. In this study, we undertook a study aimed at gaining an insight into the kind of genes expressed in the two developmentally distinct stages of gestation ie, the first trimester and term using Differential Display RT-PCR. Cloning and sequencing of one of the differentially expressed cDNAs from term placental tissue revealed that it is a novel gene, referred to as T-18 in the text. In this study, we also examined the regulation of this gene during apoptosis in the human placenta. A model for analysis of placental apoptosis was established by incubating placental villi in serum-free culture medium. It was observed that apoptosis occurred rapidly following incubation of placental villi without tropic support, and the proposed free-radical scavenger, superoxide dismutase (SOD) suppressed apoptosis in the placenta. Interestingly, the levels of T-18 mRNA increased significantly during spontaneous induction of apoptosis and decreased when apoptosis was blocked by SOD. These data clearly suggest that there is a strong correlation between the expression of T-18 and placental apoptosis and that T-18, may play a significant role in this process. Furthermore, the establishment of a defined in vitro explant culture model should facilitate elucidation of factors, which regulate apoptosis in human placenta.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009637726114
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-01-11
    Description: Mutations in DKC1 cause dyskeratosis congenita (DC), a disease characterized by premature aging and increased tumor susceptibility. The DKC1 protein binds to the box H + ACA small nucleolar RNAs and the RNA component of telomerase. Here we show that hypomorphic Dkc1 mutant (Dkc1m) mice recapitulate in the first and second generations (G1 and G2) the clinical features of DC. Dkc1m cells from G1 and G2 mice were impaired in ribosomal RNA pseudouridylation before the onset of disease. Reductions of telomere length in Dkc1m mice became evident only in later generations. These results suggest that deregulated ribosome function is important in the initiation of DC, whereas telomere shortening may modify and/or exacerbate DC.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruggero, Davide -- Grisendi, Silvia -- Piazza, Francesco -- Rego, Eduardo -- Mari, Francesca -- Rao, Pulivarthi H -- Cordon-Cardo, Carlos -- Pandolfi, Pier Paolo -- New York, N.Y. -- Science. 2003 Jan 10;299(5604):259-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biology Program, Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12522253" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia ; Animals ; Apoptosis ; Bone Marrow Cells ; Cell Cycle Proteins/*genetics/*physiology ; Colony-Forming Units Assay ; Disease Models, Animal ; Dyskeratosis Congenita/complications/*genetics/*metabolism ; Female ; Genetic Predisposition to Disease ; Hematopoietic Stem Cells/physiology ; In Situ Hybridization, Fluorescence ; Male ; Mice ; Mutation ; Neoplasms/*etiology ; Nuclear Proteins/*genetics/*physiology ; Pseudouridine/*metabolism ; RNA, Ribosomal/*metabolism ; Ribosomes/physiology ; Telomerase/metabolism ; Telomere/metabolism/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    Lithium-Ion Cell Storage Study (2000)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: This viewgraph presentation reviews the issues concerning storage of lithium ion batteries. The presentation outlines tests used to establish a best long term storage for the lithium ion cells. Another objective of the study was to determine the preferred solstice condition for the lithium ion chemistry (polymer and liquid electrolyte). It also compared voltage clamped with trickle charge storage. The tests and results are reviewed
    Keywords: Energy Production and Conversion
    Type: The 1999 NASA Aerospace Battery Workshop; 303-316; NASA/CP-2000-209959
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    In-Orbit Earth Radiation Budget Satellite (ERBS) Battery Switch (2000)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: A viewgraph presentation outlines the Earth Radiation Budget Satellite (ERBS) power system and battery history. ERBS spacecraft and battery cell failures are listed with the reasons for failure. The battery management decision and stabilization of the batteries is discussed. Present battery operations are shown to be successful.
    Keywords: Energy Production and Conversion
    Type: The 1999 NASA Aerospace Battery Workshop; 65-85; NASA/CP-2000-209959
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 5
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    Crane Cell Testing Support of NASA/Goddard Space Flight Center: An Update (2001)
    In:  CASI
    Details
    Publication Date: 2017-09-27
    Description: The objectives presented in this viewgraph presentation include: 1) Verify the quality and reliability of aerospace battery cells and batteries for NASA flight programs; 2) Disseminate the data to develop a plan for in-orbit battery management and to design a cell/battery for future NASA spacecraft; and 3) Establish a cell test data base for rechargeable cell/batteries. In summary: quality EPT Ni-H2, EPT Super NiCd and SAFT NiCd cells have been demonstrated for aerospace applications; the data has been provided to NASA Centers and other agencies for their use and application; developed plan and used in NASA in-orbit battery management. Database on rechargeable cell/batteries is now available for customer use.
    Keywords: Energy Production and Conversion
    Type: The 2000 NASA Aerospace Battery Workshop; NASA/CP-2001-210883
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 6
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    Effects of AEA Cell-Bypass-Switch Closure on Charged EOS-Aqua NiH2 Cell (2001)
    In:  CASI
    Details
    Publication Date: 2017-09-27
    Description: The nominal performance of AEA CBPD under simulated EOS-Aqua/Aura flight hardware configuration has been demonstrated. There is no evidence of cell rupture or excessive heat production during or after CBPD switch activation under simulated high cell impedance (open-circuit cell failure mode). Inadvertent CBPD switch activation with a charged cell (low impedance path) intermittently closes and opens up the switch, therefore the device may or may not provide protection against future open-circuit cell failure. Further testing with switches F01 and F02 may provide clarification. The formation of a continuous low impedance path (a homogeneous low melting point alloy), has been confirmed - which is the expected mode of operation.
    Keywords: Energy Production and Conversion
    Type: The 2000 NASA Aerospace Battery Workshop; NASA/CP-2001-210883
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 7
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    Effect of Handling, Storage and Cycling on Ni-H2 Cells: Second Plateau Phenomenon (2001)
    In:  CASI
    Details
    Publication Date: 2017-09-27
    Description: Proper handling of Ni-H2 cells/batteries in storage, during I&T, and at launch site is very important to preserve the useful energy and to extend the mission life. Cell reversal test is not a prudent test to verify or quantify the nickel pre-charge in Ni-H2 cells/batteries. The second plateau is due to the formation of Ni(+3) that is electrochemically inactive. Gas analysis of the cell, and chemical analysis of the positive plate are confirmatory tests to determine the nature of pre-charge in Ni-H2 cells.
    Keywords: Energy Production and Conversion
    Type: The 2000 NASA Aerospace Battery Workshop; NASA/CP-2001-210883
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 8
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    Lithium-Ion Small Cell Battery Shorting Study (2004)
    In:  CASI
    Details
    Publication Date: 2019-08-13
    Description: AEA performed a hard short study on various cell configurations whilst monitoring voltage, current and temperature. Video recording was also done to verify the evidence for cell venting. The presentation summarizes the results of the study including video footage of typical samples. Need for the diode protection in manned applications is identified. The standard AEA approach of using fused connectors during AIT for unmanned applications is also described.
    Keywords: Energy Production and Conversion
    Type: 2004 NASA Aerospace Battery Workshop; Nov 16, 2004 - Nov 18, 2004; Huntsville, AL; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 9
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    Low-Earth-Orbit and Geosynchronous-Earth-Orbit Testing of 80 Ah Batteries under Real-time Profiles (2004)
    In:  CASI
    Details
    Publication Date: 2019-08-13
    Description: This viewgraph presentation gives an update on test results from two 16 cell batteries, one in a simulated Low Earth Orbit (LEO) environment and the other in simulated Geosynchronous Earth Orbit (GEO) environment. The tests measured how voltage and capacity are affected over time by thermal cycling.
    Keywords: Energy Production and Conversion
    Type: 2004 NASA Aerospace Battery Workshop; Nov 16, 2004 - Nov 18, 2004; Huntsville, AL; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 10
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    The Long-Term Performance of SONY Small Batteries without Cell-Balancing (2004)
    In:  CASI
    Details
    Publication Date: 2019-08-13
    Description: This viewgraph presentation describes the investigation of individual cell voltage dispersion under LEO and GEO cycling profiles. The contents cover: 1) Background; 2) Test Outline; 3) Single String Test Battery; 4) Goddard Space Flight Center (GSFC) 5Ah Battery; 5) Impedance; 6) Conclusions.
    Keywords: Energy Production and Conversion
    Type: 2004 NASA Aerospace Battery Workshop; Nov 16, 2004 - Nov 18, 2004; Huntsville, AL; United States
    Format: text
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    NASA TECHNICAL REPORTS
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