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  • EARTH RESOURCES AND REMOTE SENSING  (36)
  • Chlorides/metabolism  (2)
  • GEOSCIENCES (GENERAL)  (2)
  • Glutamates/pharmacology  (2)
  • 1
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    Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the gamma-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences between anesthetic and anticonvulsant barbiturates, which may explain their different clinical effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macdonald, R L -- Barker, J L -- New York, N.Y. -- Science. 1978 May 19;200(4343):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205953" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Cells, Cultured ; Electric Conductivity ; Glutamates/pharmacology ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Phenobarbital/*pharmacology ; Picrotoxin/pharmacology ; Receptors, Neurotransmitter/drug effects ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, J D -- Barker, J L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1409-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cells, Cultured ; Electric Conductivity ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Membrane Potentials ; Mice ; Neural Inhibition ; Spinal Cord/cytology/*physiology ; Substance P/*physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Pentobarbital: dual actions to increase brain benzodiazepine receptor affinity (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-27
    Description: The binding of [3H]diazepam to benzodiazepine receptors was studied in extensively washed membranes of rat cerebral cortex in the presence of the depressant barbiturate, pentobarbital. Pentobarbital, like the endogenous neurotransmitter gamma-aminobutyric acid (GABA), increased the basal binding and also potentiated the GABA-enhanced binding of [3H]diazepam to benzodiazepine receptors by increasing the apparent affinity of [3H]diazepam for the benzodiazepine receptor. The concentrations of pentobarbital necessary to elicit these effects in vitro are the same as those observed after treatment with pharmacologically relevant doses, suggesting that a common neurochemical association may exist between these types of compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skolnick, P -- Moncada, V -- Barker, J L -- Paul, S M -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1448-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6258230" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/drug effects ; Chlorides/metabolism ; Diazepam/metabolism ; Male ; Pentobarbital/*pharmacology ; Rats ; Receptors, Drug/*drug effects/metabolism ; Receptors, GABA-A ; Stimulation, Chemical ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-05-23
    Description: Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3 alpha-hydroxy-5 alpha-dihydroprogesterone and 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone, are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex. At concentrations between 10(-7) and 10(-5)M both steroids inhibited binding of the convulsant t-butylbicyclophosphorothionate to the GABA-receptor complex and increased the binding of the benzodiazepine flunitrazepam; they also stimulated chloride uptake (as measured by uptake of 36Cl-) into isolated brain vesicles, and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons. These data may explain the ability of certain steroid hormones to rapidly alter neuronal excitability and may provide a mechanism for the anesthetic and hypnotic actions of naturally occurring and synthetic anesthetic steroids.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Majewska, M D -- Harrison, N L -- Schwartz, R D -- Barker, J L -- Paul, S M -- New York, N.Y. -- Science. 1986 May 23;232(4753):1004-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2422758" target="_blank"〉PubMed〈/a〉
    Keywords: 20-alpha-Dihydroprogesterone/*analogs & derivatives/metabolism/pharmacology ; Animals ; Bicyclo Compounds/metabolism ; *Bicyclo Compounds, Heterocyclic ; Binding, Competitive ; Brain/metabolism ; Cells, Cultured ; Chlorides/metabolism ; Desoxycorticosterone/*analogs & derivatives/metabolism/pharmacology ; Drug Synergism ; Flunitrazepam/metabolism ; Hippocampus/metabolism ; In Vitro Techniques ; Ion Channels/metabolism ; Progesterone/*analogs & derivatives/metabolism/pharmacology ; Rats ; Receptors, GABA-A/*drug effects/metabolism ; Spinal Cord/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Thematic Mapper bandpass solar exoatmospheric irradiances (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Based on solar irradiance data published by Neckel and Labs (1984) and Iqbal (1983), the solar exoatmospheric irradiances for Thematic Mapper (TM) bands 1, 2, 3, and 4 have been calculated. Results vary by up to 1 percent from previous published values, which were based on the earlier data of Neckel and Labs. For TM bands 5 and 7, integrated solar exoatmospheric irradiances have also been recalculated using solar irradiance data published by Labs and Neckel (1968), Arvesen et al. (1969), and Iqbal (1983). These irradiances vary by up to 6 percent from previously published results, which were based on data published by Thekaekara (1972).
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: International Journal of Remote Sensing (ISSN 0143-1161); 8; 517-523
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  • 6
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    A sampling procedure to guide the collection of narrow-band, high-resolution spatially and spectrally representative reflectance data (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: A multistage sampling procedure using image processing, geographical information systems, and analytical photogrammetry is presented which can be used to guide the collection of representative, high-resolution spectra and discrete reflectance targets for future satellite sensors. The procedure is general and can be adapted to characterize areas as small as minor watersheds and as large as multistate regions. Beginning with a user-determined study area, successive reductions in size and spectral variation are performed using image analysis techniques on data from the Multispectral Scanner, orbital and simulated Thematic Mapper, low altitude photography synchronized with the simulator, and associated digital data. An integrated image-based geographical information system supports processing requirements.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
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  • 7
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    Spectral characterization of the LANDSAT-4 thematic mapper sensors (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Data collected on the spectral characteristics of the LANDSAT-4 and LANDSAT-4 backup thematic mapper instruments, the protoflight (PF) and flight (F) models, respectively are analyzed and summarized. Tests were conducted on the instruments and their components to determine compliance with two sets of spectral specifications: Band-by-band spectral coverage and channel-by-channel within-band spectral matching.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: LANDSAT-4 Sci. Characterization; 2 p
    Format: text
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  • 8
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    Thermal band characterization of LANDSAT-4 thematic mapper (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: The TM band 6 shutter background and the 34.7 C internal black body signal were measured over 50 day dates. Variability of the shutter background temperature was from 7 C to 11 C. For ten specific images, the digital counts of the calibration data were measured. The average pulse value of the black body peak decreased from 174 to 149 counts while the shutter background counts varied as a function of shutter temperature from 77 to 85. Relative internal gains between the four channels were calculated and compared to prelaunch values. They showed gains over 9 months of up to 5%. Frequency histograms of number of pixels vs. digital counts from a night scene were used to determine gain relative to the mean and to discern a systematic along-scan pattern in a difference between forward and reverse scan counts of up to 0.5. A corrected digital image was obtained. A temperature estimate for and area of Lake Erie of 18.5 C to 19.9 C was obtained. Local temperature records showed 21 C.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: LANDSAT-4 Sci. Characterization; 3 p
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  • 9
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    TM report (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Key spectral, radiometric, and geometric characteristics of the TM sensor are examined. Spectrally, band 5 is slightly wider than specified and its upper edge at 50% of miximum of 1784 nm includes some unintended overlap with water absorption bands. Thermal band 6 is half the expected width. Radiometrically, the TM has extreme linearity and stability in comparison with previous MSS photomultiplier systems. Forward and reverse scans on TM show some unexplained radiometric differences of up to four digital levels. Primary focal plane bands show a monotomic decrease in gain of about 5% in the five months since launch. The relative internal gains of bands 5 and 7 varied with a period of about 60 days and an amplitude of about 6%. Radiometric calibration must be applied before histogram equalization algorithms to preserve radiometric accuracy. Geometrically, channel 4 in band 2 has a smaller modulation transfer function than desired. There is apparent misregistration of .75 pixels along scan and 0.2 pixels across scan.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: LANDSAT-4 Sci. Characterization; 2 p
    Format: text
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  • 10
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    LANDSAT-4 evaluation program and scientific characterization activities (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: The characterization objectives of the LANDSAT 4 Science Office at GSFC are to: (1) determine the accuracy and precision of sensor and spacecraft performance, image data quality, and derived information; (2) recommend LANDSAT 4 system improvements; and (3) communicate results to the research community. In-house activities are directed toward full access and utilization of the prelaunch and in-orbit engineering test data on the sensor and spacecraft. Principle scientists in remote sensing are involved as part of a major scientific characterization effort, and workshops were held for these investigative teams. A symposium is scheduled prior to turnover of the TM to NOAA.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: LANDSAT-4 Sci. Characterization; 2 p
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