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  • 1
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    An ABC transporter controls export of a Drosophila germ cell attractant (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-14
    Description: Directed cell migration, which is critical for embryonic development, leukocyte trafficking, and cell metastasis, depends on chemoattraction. 3-hydroxy-3-methylglutaryl coenzyme A reductase regulates the production of an attractant for Drosophila germ cells that may itself be geranylated. Chemoattractants are commonly secreted through a classical, signal peptide-dependent pathway, but a geranyl-modified attractant would require an alternative pathway. In budding yeast, pheromones produced by a-cells are farnesylated and secreted in a signal peptide-independent manner, requiring the adenosine triphosphate-binding cassette (ABC) transporter Ste6p. Here we show that Drosophila germ cell migration uses a similar pathway, demonstrating that invertebrate germ cells, like yeast cells, are attracted to lipid-modified peptides. Components of this unconventional export pathway are highly conserved, suggesting that this pathway may control the production of similarly modified chemoattractants in organisms ranging from yeast to humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729540/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729540/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ricardo, Sara -- Lehmann, Ruth -- HD49100/HD/NICHD NIH HHS/ -- R01 HD041900/HD/NICHD NIH HHS/ -- R01 HD041900-08/HD/NICHD NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2009 Feb 13;323(5916):943-6. doi: 10.1126/science.1166239.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York University, 540 First Avenue, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19213920" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/genetics/metabolism ; Animals ; Biological Transport ; Chemotaxis/*physiology ; Diterpenes/metabolism ; Drosophila Proteins/genetics/metabolism/*physiology ; Drosophila melanogaster ; Genetic Complementation Test ; Germ Cells/*physiology ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Mesoderm/cytology/metabolism ; P-Glycoproteins/genetics/metabolism/*physiology ; Protein Prenylation ; Protein Sorting Signals ; Saccharomyces cerevisiae Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-10-28
    Description: The spindle assembly checkpoint guards the fidelity of chromosome segregation. It requires the close cooperation of cell cycle regulatory proteins and cytoskeletal elements to sense spindle integrity. The role of the centrosome, the organizing center of the microtubule cytoskeleton, in the spindle checkpoint is unclear. We found that the molecular requirements for a functional spindle checkpoint included components of the large gamma-tubulin ring complex (gamma-TuRC). However, their localization at the centrosome and centrosome integrity were not essential for this function. Thus, the spindle checkpoint can be activated at the level of microtubule nucleation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, Hannah -- Fogeron, Marie-Laure -- Lehmann, Verena -- Lehrach, Hans -- Lange, Bodo M H -- New York, N.Y. -- Science. 2006 Oct 27;314(5799):654-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17068266" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle Proteins/metabolism ; Cell Line ; Centrosome/physiology ; Drosophila Proteins/genetics/*metabolism ; Drosophila melanogaster ; Homeodomain Proteins/genetics/metabolism ; Humans ; Kinetochores/metabolism ; Microtubule-Associated Proteins/genetics/*metabolism ; Microtubules/ultrastructure ; *Mitosis ; Protein Kinases/metabolism ; Protein-Serine-Threonine Kinases ; RNA Interference ; Spindle Apparatus/*metabolism/ultrastructure ; Tubulin/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Mutations of early neurogenesis inDrosophila (1981)
    Springer
    Development genes and evolution 190 (1981), S. 226-229 
    Details
    ISSN: 1432-041X
    Keywords: Early neurogenesis ; Mutants ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Embryonic lethal mutations at the Notch locus are known to produce a conspicuous central nervous system hypertrophy accompanied by a hypotrophy of the epidermal sheath. We have studied several zygotic mutants belonging to four different autosomal complementation groups which produce the same phenotype. The embryonic development of the new mutants, as well as that of Notch, consists of an initial enlargement of the neurogenic region at the expenses of epidermal cell precursors. The possibility is discussed that these five loci are involved in the determination of neural and epidermal cell precursors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848307
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  • 4
    Electronic Resource
    Electronic Resource
    Co-mutagenic effect of tannic acid on ring-X chromosome loss induced by mitomycin C in sperm cells of Drosophila melanogaster
    Amsterdam : Elsevier
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 308 (1994), S. 143-148 
    Details
    ISSN: 0027-5107
    Keywords: Co-mutagenic effect ; Drosophila melanogaster ; Methyl methanesulfonate ; Mitomycin C ; Ring-X loss ; Tannic acid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0027-5107(94)90149-X
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  • 5
    Electronic Resource
    Electronic Resource
    P element regulation and X-chromosome subtelomeric heterochromatin in Drosophila melanogaster (1997)
    Springer
    Genetica 100 (1997), S. 95-107 
    Details
    ISSN: 1573-6857
    Keywords: Drosophila melanogaster ; heterochromatin ; P element ; telomere ; transposition regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In Drosophila melanogaster, crossing males carrying autonomous P elements with females devoid of P copies results in hybrid dysgenesis in the germline of progeny. The reciprocal cross produces non-dysgenic progeny due to a maternally inherited state non-permissive for P transposition. The capacity of a P copy to repress transposition depends on both its structure and its chromosomal location. Naturally occuring regulatory P elements inserted at the telomere of the X chromosome have been genetically isolated in a genomic context devoid of other P elements. One or two copies of autonomous P elements at this site (1A) are sufficient to elicit a strong P repression in the germline. These elements are flanked by Telomeric Associated Sequences, previously identified and described by Karpen and Spradling (1992) as having heterochromatic properties. The regulatory properties of P elements at 1A are strongly impaired by mutations affecting Su(var)205, which encodes Heterochromatin Protein 1, a non-histone heterochromatin protein. The regulatory properties of classical P strains are not sensitive to Su(var)205. Models based on chromatin structure or on nuclear localisation of the telomeres are discussed in order to explain both the strong regulatory properties of P elements at the X chromosome telomere and their sensitivity to Su(var)205.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018356906932
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  • 6
    Electronic Resource
    Electronic Resource
    Ambient temperature affects free-flight performance in the fruit fly Drosophila melanogaster (1999)
    Springer
    Journal of comparative physiology 169 (1999), S. 165-171 
    Details
    ISSN: 1432-136X
    Keywords: Key words Free flight ; Flight force ; Muscle mechanical power ; Thermal sensitivity ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To gain insight into how temperature affects locomotor performance in insects, the limits of flight performance have been estimated in freely flying fruit flies Drosophila melanogaster by determining the maximum load that a fly could carry following take-off. At a low ambient temperature of 15 °C, muscle mechanical power output matches the minimum power requirements for hovering flight. Aerodynamic force production rises with increasing temperature and eventually saturates at a flight force that is roughly equal to 2.1 times the body mass. Within the two-fold range of different body sizes, maximum flight force production during free flight does not decrease with decreasing body size as suggested by standard aerodynamic theories. Estimations of flight muscle mechanical power output yields a peak performance of 110 W kg−1 muscle tissue for short-burst flight that was measured at an ambient temperature of 30 °C. With respect to the uncertainties in estimating muscle mechanical power during free flight, the estimated values are similar to those that were published for flight under tethered flight conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003600050207
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