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    The genomic signature of dog domestication reveals adaptation to a starch-rich diet (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-01-29
    Description: The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs and wolves to identify 3.8 million genetic variants used to identify 36 genomic regions that probably represent targets for selection during dog domestication. Nineteen of these regions contain genes important in brain function, eight of which belong to nervous system development pathways and potentially underlie behavioural changes central to dog domestication. Ten genes with key roles in starch digestion and fat metabolism also show signals of selection. We identify candidate mutations in key genes and provide functional support for an increased starch digestion in dogs relative to wolves. Our results indicate that novel adaptations allowing the early ancestors of modern dogs to thrive on a diet rich in starch, relative to the carnivorous diet of wolves, constituted a crucial step in the early domestication of dogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Axelsson, Erik -- Ratnakumar, Abhirami -- Arendt, Maja-Louise -- Maqbool, Khurram -- Webster, Matthew T -- Perloski, Michele -- Liberg, Olof -- Arnemo, Jon M -- Hedhammar, Ake -- Lindblad-Toh, Kerstin -- England -- Nature. 2013 Mar 21;495(7441):360-4. doi: 10.1038/nature11837. Epub 2013 Jan 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 75237 Uppsala, Sweden. Erik.Axelsson@imbim.uu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23354050" target="_blank"〉PubMed〈/a〉
    Keywords: Amylases/genetics ; Animals ; Animals, Domestic/*genetics ; Diet/*veterinary ; Dogs/*genetics ; Genome/*genetics ; Glycogen Storage Disease Type II ; Mutation ; *Starch ; Wolves/genetics ; alpha-Glucosidases/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    A mutation in hairless dogs implicates FOXI3 in ectodermal development (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-09-13
    Description: Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Drogemuller, Cord -- Karlsson, Elinor K -- Hytonen, Marjo K -- Perloski, Michele -- Dolf, Gaudenz -- Sainio, Kirsi -- Lohi, Hannes -- Lindblad-Toh, Kerstin -- Leeb, Tosso -- New York, N.Y. -- Science. 2008 Sep 12;321(5895):1462. doi: 10.1126/science.1162525.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Berne, 3001 Berne, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18787161" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Chromosome Mapping ; Dog Diseases/*genetics ; Dogs/*genetics ; Ectoderm/*embryology/metabolism ; Ectodermal Dysplasia/genetics/*veterinary ; Ectodysplasins/metabolism ; Female ; Forkhead Transcription Factors/chemistry/*genetics/physiology ; *Frameshift Mutation ; Gene Duplication ; Hair/embryology/metabolism ; Haplotypes ; Male ; Mice ; Molecular Sequence Data ; Mutant Proteins/chemistry/genetics/physiology ; Pedigree ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA ; Signal Transduction ; Tooth/embryology/metabolism ; Vibrissae/embryology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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