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  • 1
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    The genomic signature of dog domestication reveals adaptation to a starch-rich diet (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-01-29
    Description: The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs and wolves to identify 3.8 million genetic variants used to identify 36 genomic regions that probably represent targets for selection during dog domestication. Nineteen of these regions contain genes important in brain function, eight of which belong to nervous system development pathways and potentially underlie behavioural changes central to dog domestication. Ten genes with key roles in starch digestion and fat metabolism also show signals of selection. We identify candidate mutations in key genes and provide functional support for an increased starch digestion in dogs relative to wolves. Our results indicate that novel adaptations allowing the early ancestors of modern dogs to thrive on a diet rich in starch, relative to the carnivorous diet of wolves, constituted a crucial step in the early domestication of dogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Axelsson, Erik -- Ratnakumar, Abhirami -- Arendt, Maja-Louise -- Maqbool, Khurram -- Webster, Matthew T -- Perloski, Michele -- Liberg, Olof -- Arnemo, Jon M -- Hedhammar, Ake -- Lindblad-Toh, Kerstin -- England -- Nature. 2013 Mar 21;495(7441):360-4. doi: 10.1038/nature11837. Epub 2013 Jan 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 75237 Uppsala, Sweden. Erik.Axelsson@imbim.uu.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23354050" target="_blank"〉PubMed〈/a〉
    Keywords: Amylases/genetics ; Animals ; Animals, Domestic/*genetics ; Diet/*veterinary ; Dogs/*genetics ; Genome/*genetics ; Glycogen Storage Disease Type II ; Mutation ; *Starch ; Wolves/genetics ; alpha-Glucosidases/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Diet adaptation in ancient dogs (2016)
    Royal Society
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    Publication Date: 2016-11-11
    Description: Extant dog and wolf DNA indicates that dog domestication was accompanied by the selection of a series of duplications on the Amy2B gene coding for pancreatic amylase. In this study, we used a palaeogenetic approach to investigate the timing and expansion of the Amy2B gene in the ancient dog populations of Western and Eastern Europe and Southwest Asia. Quantitative polymerase chain reaction was used to estimate the copy numbers of this gene for 13 ancient dog samples, dated to between 15 000 and 4000 years before present (cal. BP). This evidenced an increase of Amy2B copies in ancient dogs from as early as the 7th millennium cal. BP in Southeastern Europe. We found that the gene expansion was not fixed across all dogs within this early farming context, with ancient dogs bearing between 2 and 20 diploid copies of the gene. The results also suggested that selection for the increased Amy2B copy number started 7000 years cal. BP, at the latest. This expansion reflects a local adaptation that allowed dogs to thrive on a starch rich diet, especially within early farming societies, and suggests a biocultural coevolution of dog genes and human culture.
    Keywords: evolution
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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