Publication Date:
1982-03-19
Description:
The finding that some opioid-mediated forms of stress-induced analgesia are antagonized by hypophysectomy and dexamethasone has led to the suggestion that beta-endorphin, released from the pituitary, may mediate these analgesic reactions. "Long-term analgesia" (an opioid-mediated form of stress-induced analgesia), which is blocked by dexamethasone and hypophysectomy, was also blocked by adrenalectomy and reinstated with corticosterone therapy. Corticosterone is proposed to play a permissive role in long-term analgesia and to be a critical hormone mediating this phenomenon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacLennan, A J -- Drugan, R C -- Hyson, R L -- Maier, S F -- Madden, J 4th -- Barchas, J D -- MH 23861/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1530-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063862" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenalectomy
;
Analgesia
;
Animals
;
Corticosterone/*physiology
;
Dexamethasone/pharmacology
;
Endorphins/*physiology
;
Hypophysectomy
;
Pain/*physiopathology
;
Rats
;
Stress, Physiological/*physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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