Publication Date:
2009-10-10
Description:
The definitive mammalian middle ear (DMME) is defined by the loss of embryonic Meckel's cartilage and disconnection of the middle ear from the mandible in adults. It is a major feature distinguishing living mammals from nonmammalian vertebrates. We report a Cretaceous trechnotherian mammal with an ossified Meckel's cartilage in the adult, showing that homoplastic evolution of the DMME occurred in derived therian mammals, besides the known cases of eutriconodonts. The mandible with ossified Meckel's cartilage appears to be paedomorphic. Reabsorption of embryonic Meckel's cartilage to disconnect the ear ossicles from the mandible is patterned by a network of genes and signaling pathways. This fossil suggests that developmental heterochrony and gene patterning are major mechanisms in homplastic evolution of the DMME.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ji, Qiang -- Luo, Zhe-Xi -- Zhang, Xingliao -- Yuan, Chong-Xi -- Xu, Li -- New York, N.Y. -- Science. 2009 Oct 9;326(5950):278-81. doi: 10.1126/science.1178501.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19815774" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Biological Evolution
;
Cartilage/embryology/physiology
;
Chondrogenesis
;
Dentition
;
Ear Ossicles/anatomy & histology/embryology
;
*Ear, Middle/anatomy & histology/embryology
;
Embryo, Mammalian/anatomy & histology
;
*Fossils
;
Gene Expression Regulation, Developmental
;
Intercellular Signaling Peptides and Proteins/metabolism
;
*Mammals/anatomy & histology/classification/embryology/genetics
;
Mandible/anatomy & histology
;
Mice
;
Mice, Mutant Strains
;
*Osteogenesis
;
Phylogeny
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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