ISSN:
1432-072X
Schlagwort(e):
Ophiocordin
;
Antifungal antibiotic
;
Cordyceps ophioglossoides
;
Culture conditions
;
Isolation
;
Analytical data
;
Partial structure
;
Biological properties
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
Notizen:
Abstract An unknown antibiotic, ophiocordin, C21H22N2O8, MW: 430, was isolated from submerged cultures of Cordyceps ophioglossoides, strain TÜ 276, grown in a glycerol soybean meal medium at 27°C. The antibiotic was extracted from acidified culture fluids with n-butanol and purified by subsequent column chromatography on DEAE-Sephadex and cellulose. Studies including nuclear magnetic resonance and mass spectrometry resulted in proposals of partial structures of the molecule. Inhibition by ophiocordin could be demonstrated for a small number of fungi belonging to different taxonomic groups. Bacteria were not inhibited. The antifungal effect was antagonized by ammonia and nitrate ions and by certain amino acids.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00428591
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