ISSN:
1612-1112
Keywords:
Gas chromatography
;
Stationary phase optimization
;
Mobile phase optimization
;
Column temperature optimization
;
Multifactor optimization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A computer-assisted method is presented for the simultaneous multifactor optimization (stationary phase loading, column temperature and carrier gas flow rate) of the analytical conditions for the optimum separation of multicomponent samples in gas chromatography. The optimization of the separation over the experimental region is based on a special polynomial from twelve preliminary experiments using the resolution as the selection criterion. Computer scanning technique was used for optimum selection in three dimensions. Excellent agreement was obtained between the predicted data and the experimental results.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02274569
Permalink
