Summary
A computer-assisted method is presented for the simultaneous multifactor optimization (stationary phase loading, column temperature and carrier gas flow rate) of the analytical conditions for the optimum separation of multicomponent samples in gas chromatography. The optimization of the separation over the experimental region is based on a special polynomial from twelve preliminary experiments using the resolution as the selection criterion. Computer scanning technique was used for optimum selection in three dimensions. Excellent agreement was obtained between the predicted data and the experimental results.
This is a preview of subscription content, log in via an institution to check access.
References
S. L. Morgan, S. N. Deming, J. Chromatogr.,112, 267 (1975).
E. V. Dose, Anal. Chem.,59, 2420 (1987).
S. L. Morgan, C. A. Jacques, J. Chromatogr. Sci.,16, 500 (1978).
W. Czelakowski, P. Kusz, A. Andrysiak, Chromatographia,22, 278 (1986).
Q. S. Wang, D. M. Chen, Chinese J. Chromatogr.,5, 171 (1987).
B. S. Lin, H. C. Li, P. C. Lu, Chinese J. Chromatogr.4, 193 (1986).
H. Y. Wang, Master of Science thesis. Nankai University, Tianjin, P.R. China (1988).
E. Matisova, E. Kovacicova, J. Garaj, G. Kraus, Chromatographia,27, 494 (1989).
M. G. Xie, C. F. Zhou, X. H. Yang, G. Y. Ding, Chromatographia,28, 274 (1989).
Q. S. Wang, C. S. Zhu, B. W. Yan, J. Chromatogr.,513, 13 (1990).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wang, Q.S., Zhu, C.S., Yan, B.W. et al. Computer-assisted multifactor optimization of selectivity in gas chromatography. Chromatographia 31, 173–176 (1991). https://doi.org/10.1007/BF02274569
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02274569