Publication Date:
2009-05-26
Description:
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834264/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834264/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Geraldine -- Rasmussen, Matthew D -- Lin, Michael F -- Santos, Manuel A S -- Sakthikumar, Sharadha -- Munro, Carol A -- Rheinbay, Esther -- Grabherr, Manfred -- Forche, Anja -- Reedy, Jennifer L -- Agrafioti, Ino -- Arnaud, Martha B -- Bates, Steven -- Brown, Alistair J P -- Brunke, Sascha -- Costanzo, Maria C -- Fitzpatrick, David A -- de Groot, Piet W J -- Harris, David -- Hoyer, Lois L -- Hube, Bernhard -- Klis, Frans M -- Kodira, Chinnappa -- Lennard, Nicola -- Logue, Mary E -- Martin, Ronny -- Neiman, Aaron M -- Nikolaou, Elissavet -- Quail, Michael A -- Quinn, Janet -- Santos, Maria C -- Schmitzberger, Florian F -- Sherlock, Gavin -- Shah, Prachi -- Silverstein, Kevin A T -- Skrzypek, Marek S -- Soll, David -- Staggs, Rodney -- Stansfield, Ian -- Stumpf, Michael P H -- Sudbery, Peter E -- Srikantha, Thyagarajan -- Zeng, Qiandong -- Berman, Judith -- Berriman, Matthew -- Heitman, Joseph -- Gow, Neil A R -- Lorenz, Michael C -- Birren, Bruce W -- Kellis, Manolis -- Cuomo, Christina A -- BB/F00513X/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/F013566/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- G0400284/Medical Research Council/United Kingdom -- HHSN266200400001C/AO/NIAID NIH HHS/ -- R01 AI050113/AI/NIAID NIH HHS/ -- R01 AI075096/AI/NIAID NIH HHS/ -- R01 DE015873/DE/NIDCR NIH HHS/ -- R01 HG004037/HG/NHGRI NIH HHS/ -- R01 HG004037-02/HG/NHGRI NIH HHS/ -- U54 HG003067/HG/NHGRI NIH HHS/ -- U54 HG003067-06/HG/NHGRI NIH HHS/ -- Wellcome Trust/United Kingdom -- England -- Nature. 2009 Jun 4;459(7247):657-62. doi: 10.1038/nature08064.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. geraldine.butler@ucd.ie〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19465905" target="_blank"〉PubMed〈/a〉
Keywords:
Candida/classification/genetics/*pathogenicity/*physiology
;
Codon/genetics
;
Conserved Sequence
;
Diploidy
;
*Evolution, Molecular
;
Genes, Fungal/genetics
;
Genome, Fungal/*genetics
;
Meiosis/genetics
;
Polymorphism, Genetic
;
Reproduction/*genetics
;
Saccharomyces/classification/genetics
;
Virulence/genetics
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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